Introduction: Cystic fibrosis is an autosomal recessive disorder caused by mutations in the
cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for the CFTR …

The ability to regulate cell volume is crucial for normal physiology; equally the regulation of
extracellular fluid homeostasis is of great importance. Alteration of normal extracellular fluid …

Orai1 is a plasma membrane Ca2+ channel that mediates store-operated Ca2+ entry
(SOCE) and regulates inflammation. Short palate lung and nasal epithelial clone 1 …

Rationale: Acute respiratory distress syndrome (ARDS) has an unacceptably high mortality
rate (35%) and is without effective therapy. Orai1 is a Ca2+ channel involved in store …

Background Acute pulmonary exacerbations (AE) are episodes of clinical worsening in
cystic fibrosis (CF), often precipitated by infection. Timely detection is critical to minimise …

Bactericidal/permeability-increasing protein (BPI) is an anti-microbial protein predominantly
expressed in azurophilic granules of neutrophils. BPI has been shown to mediate cytocidal …

Bacterial permeability family member A1 (BPIFA1), also known as short palate, lung, and
nasal epithelium clone 1 (SPLUNC1), is a protein involved in the antiinflammatory response …

Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal
inflammatory response in the lungs caused by the inhalation of noxious particles and gases …

A previous study involving a proteomic screen of induced sputum from smokers and patients
with chronic obstructive pulmonary disease (COPD) demonstrated elevated levels of …

Genome wide association studies (GWAS) have identified several genomic loci with
candidate modifiers of cystic fibrosis (CF) lung disease, but only a small proportion of the …