The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Oral administration is the preferred route of drug delivery in clinical practice due to its
noninvasiveness, safety, convenience, and high patient compliance. The gastrointestinal …

The transient receptor potential (TRP) channel superfamily consists of a large group of non-
selective cation channels that serve as cellular sensors for a wide spectrum of physical and …

The first genuine high-resolution single particle cryo-electron microscopy structure of a
membrane protein determined was a transient receptor potential (TRP) ion channel, TRPV1 …

Metastasis is the hallmark of failed tumor treatment and is typically associated with death
due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular …

Abstract The old Greek saying “Panta Rhei”(“everything flows”) is true for all life and all living
things in general. It also becomes nicely evident when looking closely into cells. There …

Lysosomal storage diseases (LSDs) resulting from inherited gene mutations constitute a
family of disorders that disturb lysosomal degradative function leading to abnormal storage …

Neurodegenerative diseases (ND) pose a serious health burden to society and healthcare
systems alike, with increasing incidence rates especially within aging populations …

Transient receptor potential (TRP) channels are a class of transmembrane proteins that can
sense a variety of physical/chemical stimuli, participate in the pathological processes of …

Ion channel is an integral membrane protein that allows the permeation of charge ions
across hydrophobic phospholipid membranes, including plasma membranes and organelle …