[HTML][HTML] Promises and challenges of human computational ethology

D Mobbs, T Wise, N Suthana, N Guzmán… - Neuron, 2021 - cell.com
The movements an organism makes provide insights into its internal states and motives.
This principle is the foundation of the new field of computational ethology, which links rich …

A decision architecture for safety computations

SM Tashjian, TD Zbozinek, D Mobbs - Trends in Cognitive Sciences, 2021 - cell.com
Accurately estimating safety is critical to pursuing nondefensive survival behaviors.
However, little attention has been paid to how the human brain computes safety. We …

Model-based aversive learning in humans is supported by preferential task state reactivation

T Wise, Y Liu, F Chowdhury, RJ Dolan - Science Advances, 2021 - science.org
Harm avoidance is critical for survival, yet little is known regarding the neural mechanisms
supporting avoidance in the absence of trial-and-error experience. Flexible avoidance may …

Interactive cognitive maps support flexible behavior under threat

T Wise, CJ Charpentier, P Dayan, D Mobbs - Cell reports, 2023 - cell.com
In social environments, survival can depend upon inferring and adapting to other agents'
goal-directed behavior. However, it remains unclear how humans achieve this, despite the …

Survival in a world of complex dangers

D Mobbs, T Wise, S Tashjian, JJ Zhang… - Neuroscience & …, 2024 - Elsevier
How do nomadic animals, including humans, continually adapt to the dual challenge of
recurrent threats and the seemingly limitless and unpredictable, number of dangers in the …

Subregions in the ventromedial prefrontal cortex integrate threat and protective information to meta-represent safety

SM Tashjian, J Cussen, W Deng, B Zhang… - PLoS biology, 2025 - journals.plos.org
Pivotal to self-preservation is the ability to identify when we are safe and when we are in
danger. Previous studies have focused on safety estimations based on the features of …

An intracranial dissection of human escape circuits

H Zhang, J Cheng, K Hu, F Wang, S Qi, Q Liu, Y Yao… - bioRxiv, 2024 - biorxiv.org
Predators attack at different spatiotemporal scales, spurring prey to elicit escape responses
that range from simple motor reactions and strategic planning that involve more complex …

Adaptive Safety Coding in the Prefrontal Cortex

SM Tashjian, J Cussen, W Deng, B Zhang, D Mobbs - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Pivotal to self-preservation is the ability to identify when we are safe and when we are in
danger. Previous studies have focused on safety estimations based on the features of …