Targeting angiogenesis in oncology, ophthalmology and beyond

Y Cao, R Langer, N Ferrara - Nature Reviews Drug Discovery, 2023 - nature.com
Angiogenesis is an essential process in normal development and in adult physiology, but
can be disrupted in numerous diseases. The concept of targeting angiogenesis for treating …

Diabetic retinopathy: Looking forward to 2030

TE Tan, TY Wong - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetic retinopathy (DR) is the major ocular complication of diabetes mellitus, and is a
problem with significant global health impact. Major advances in diagnostics, technology …

Diabetic macular edema: current understanding, molecular mechanisms and therapeutic implications

J Zhang, J Zhang, C Zhang, J Zhang, L Gu, D Luo… - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), with increasing incidence, is the major cause of vision loss and
blindness worldwide in working-age adults. Diabetic macular edema (DME) remains the …

[HTML][HTML] Solid implantable devices for sustained drug delivery

E Magill, S Demartis, E Gavini, AD Permana… - Advanced Drug Delivery …, 2023 - Elsevier
Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug
administration routes. Oral and injectable drug administration are the most common routes …

Age-related macular degeneration: a review

M Fleckenstein, S Schmitz-Valckenberg… - JAMA, 2024 - jamanetwork.com
Importance Age-related macular degeneration (AMD) affects approximately 20 million
people in the US and 196 million people worldwide. AMD is a leading cause of severe …

Current and novel therapeutic approaches for treatment of neovascular age-related macular degeneration

RH ElSheikh, MZ Chauhan, AB Sallam - Biomolecules, 2022 - mdpi.com
Age-related macular degeneration AMD is one of the leading causes of blindness in the
elderly population. An advanced form of AMD known as neovascular AMD (nAMD) is …

A linkage between angiogenesis and inflammation in neovascular age-related macular degeneration

H Heloterä, K Kaarniranta - Cells, 2022 - mdpi.com
Age-related macular degeneration (AMD) is the leading cause of visual impairment in the
aging population with a limited understanding of its pathogenesis and the number of …

[HTML][HTML] Novel and investigational therapies for wet and dry age-related macular degeneration

A Sarkar, SJ Sodha, V Junnuthula, P Kolimi… - Drug discovery today, 2022 - Elsevier
Age-related macular degeneration (AMD) is a macular degenerative eye disease, the major
cause of irreversible loss of central vision. In this review, we highlight current progress and …

A new era in posterior segment ocular drug delivery: Translation of systemic, cell-targeted, dendrimer-based therapies

RM Kannan, I Pitha, KS Parikh - Advanced Drug Delivery Reviews, 2023 - Elsevier
Vision impairment and loss due to posterior segment ocular disorders, including age-related
macular degeneration and diabetic retinopathy, are a rapidly growing cause of disability …

[PDF][PDF] Progress and challenges of anti-VEGF agents and their sustained-release strategies for retinal angiogenesis

M Xu, R Fan, X Fan, Y Shao, X Li - Drug design, development and …, 2023 - Taylor & Francis
Currently, the treatment for ocular neovascular diseases, including diabetic macular edema
(DME) and age-related macular degeneration (AMD), mainly involves repeated intravitreal …