Targeting intracellular galectins for cancer treatment

R Nehmé, Y St-Pierre - Frontiers in Immunology, 2023 - frontiersin.org
Although considerable attention has been paid to the role of extracellular galectins in
modulating, positively or negatively, tumor growth and metastasis, we have witnessed a …

Functions and inhibition of galectin-7, an emerging target in cellular pathophysiology

NV Sewgobind, S Albers, RJ Pieters - Biomolecules, 2021 - mdpi.com
Galectin-7 is a soluble unglycosylated lectin that is able to bind specifically to β-
galactosides. It has been described to be involved in apoptosis, proliferation and …

Galectin-7 in epithelial homeostasis and carcinomas

T Advedissian, F Deshayes, M Viguier - International journal of molecular …, 2017 - mdpi.com
Galectins are small unglycosylated soluble lectins distributed both inside and outside the
cells. They share a conserved domain for the recognition of carbohydrates (CRD). Although …

Galectin-7 impairs placentation and causes preeclampsia features in mice

E Menkhorst, W Zhou, LL Santos, S Delforce, T So… - …, 2020 - Am Heart Assoc
Preeclampsia is a serious pregnancy-induced disorder unique to humans. The etiology of
preeclampsia is poorly understood; however, poor placental formation is thought causal …

Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment

JC Higareda-Almaraz, JS Ruiz-Moreno, J Klimentova… - BMC cancer, 2016 - Springer
Abstract Background Galectin-7 (Gal-7) is negatively regulated in cervical cancer, and
appears to be a link between the apoptotic response triggered by cancer and the anti …

Human milk oligosaccharide specificities of human galectins. Comparison of electrospray ionization mass spectrometry and glycan microarray screening results

K Shams-Ud-Doha, EN Kitova, PI Kitov… - Analytical …, 2017 - ACS Publications
The affinities of thirty-two free human milk oligosaccharides (HMOs) for four human galectin
proteins, a stable mutant of hGal1 (hGal-1), a C-terminal fragment of hGal-3 (hGal-3C), hGal …

Galectins in prostate and bladder cancer: tumorigenic roles and clinical opportunities

N Martinez-Bosch, A Rodriguez-Vida… - Nature Reviews …, 2019 - nature.com
Advanced prostate and bladder cancer are two outstanding unmet medical needs for
urological oncologists. The high prevalence of these tumours, lack of effective biomarkers …

E-cadherin dynamics is regulated by galectin-7 at epithelial cell surface

T Advedissian, V Proux-Gillardeaux, R Nkosi… - Scientific Reports, 2017 - nature.com
Re-epithelialisation of wounded epidermis is ensured by collective cell migration of
keratinocytes. Efficient collective migration requires the maintenance of intercellular …

[HTML][HTML] The role of galectins in tumor progression, treatment and prognosis of gynecological cancers

M Chetry, S Thapa, X Hu, Y Song, J Zhang… - Journal of …, 2018 - ncbi.nlm.nih.gov
Galectins are the member of soluble proteins that bind with β-galactoside containing
glycans. These proteins have been considered to be associated in various important events …

Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs

NA Pinto, MC Abba, L Laporte, JM Pérez Sáez… - Cell Death & …, 2023 - nature.com
Non-melanoma skin cancer (NMSC) has risen dramatically as a result of chronic exposure
to sunlight ultraviolet (UV) radiation, climatic changes and clinical conditions associated with …