Oxidative damage and inflammation have been pointed out in preclinical studies as the root
cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer's …

Obligately intracytosolic rickettsiae that cycle between arthropod and vertebrate hosts cause
human diseases with a spectrum of severity, primarily by targeting microvascular endothelial …

Adaptive responses to sepsis are necessary to prevent organ failure and death. Cellular
signaling responses that limit cell death and structural damage allow a cell to withstand …

Heme oxygenase-1 (HO-1) is a stress-inducible, anti-inflammatory, and cytoprotective
enzyme expressed in most cell types in the organism. Under several stress stimuli, HO-1 …

Background The toxicity of high-concentration carbon monoxide (CO) on human health has
previously been documented. However, the epidemiological evidence on the association …

Enzymatic haem catabolism by haem oxygenases is conserved from bacteria to humans
and proceeds through a common mechanism leading to the formation of iron, carbon …

The possibility of a" post-antibiotic era" in the 21st century, in which common infections may
kill, has prompted research into radically new antimicrobials. CO-releasing molecules …

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most
economically important viruses affecting the swine industry worldwide. Our previous …

Visceral leishmaniasis (VL) remains a major public health problem worldwide. This disease
is highly associated with chronic inflammation and a lack of the cellular immune responses …

Ebola virus (EBOV) is the causative agent of a severe hemorrhagic fever in humans with
reported case fatality rates as high as 90%. There are currently no licensed vaccines or …