Almost all of the key molecules involved in the innate and adaptive immune response are
glycoproteins. In the cellular immune system, specific glycoforms are involved in the folding …

The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

▪ Abstract The conversion of exogenous and endogenous proteins into immunogenic
peptides recognized by T lymphocytes involves a series of proteolytic and other enzymatic …

To initiate adaptative cytotoxic immune responses, proteolytic peptides derived from
phagocytosed antigens are presented by dendritic cells (DCs) to CD8+ T lymphocytes …

The death morphology commonly known as apoptosis results from a post-translational
pathway driven largely by specific limited proteolysis. In the last decade the structural basis …

▪ Abstract The separation of sister chromatids at the metaphase to anaphase transition is
one of the most dramatic of all cellular events and is a crucial aspect of all sexual and …

Immune regulation by parasites is a global concept that includes suppression, diversion,
and conversion of the host immune response to the benefit of the pathogen. While many …

Like macrophages and neutrophils, dendritic cells (DCs) are considered professional
phagocytes. Even if the three cell types phagocytose parasites, bacteria, cell debris, or even …

Genome sequencing projects have ushered biological research into a new age where
scientists are confronted with the daunting undertaking of assigning functions to the full …

Proteases can be categorized based on their substrate specificities or mechanisms of
catalysis. Enzymes cleaving within a polypeptide chain are named endopeptidases, and …