Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

Time-restricted feeding (TRF) has recently gained interest as a potential anti-ageing
treatment for organisms from Drosophila to humans,,,–. TRF restricts food intake to specific …

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …

Various behavioral and physiological pathways follow a pre-determined, 24 hour cycle
known as the circadian rhythm. Metabolic homeostasis is regulated by the circadian rhythm …

The gut microbiome is well known to impact host physiology and health. Given widespread
control of physiology by circadian clocks, we asked how the microbiome interacts with …

Almost all living organisms have evolved autoregulatory transcriptional‐translational
feedback loops that produce oscillations with a period of approximately 24‐h. These …

The proliferation in the rate of diagnosis of obesity and type 2 diabetes mellitus continues
unabated, with current recommendations for primary lifestyle changes (ie modification to …

Genetic and pharmacological interventions have successfully extended healthspan and
lifespan in animals, but their genetic interventions are not appropriate options for human …

Context Time-restricted eating (TRE), which restricts food intake to a limited duration of the
day, is a key regimen of intermittent fasting. Objective The aim of our study was to provide an …