Radiotherapy aims to achieve a high tumor control probability while minimizing damage to
normal tissues. Personalizing radiotherapy treatments for individual patients, therefore …

Improvements in radiotherapy delivery have enabled higher therapeutic doses and
improved efficacy, contributing to the growing number of long-term cancer survivors. These …

Background: Polygenic risk scores (PRS) are linear combinations of genetic markers
weighted by effect size that are commonly used to predict disease risk. For complex …

Within the framework of precision medicine, the stratification of individual genetic
susceptibility based on inherited DNA variation has paramount relevance. However, one of …

Simple Summary Polygenic risk scores (PRSs) have been used to predict the risk of
developing cancer. However, whether PRSs are associated with immune infiltration in solid …

Background: radiotherapy is a cornerstone of cancer treatment. When delivering a
tumoricidal dose, the risk of severe late toxicities is usually kept below 5% using dose …

Risk prediction and disease prevention are the innovative care challenges of the 21st
century. Apart from freeing the individual from the pain of disease, it will lead to low medical …

In The Lancet Oncology, Jacob Scott and colleagues1 describe an algorithm using the
genomic-adjusted radiation dose (GARD) to personalise radiotherapy dose prescription on …

Polygenic risk score (PRS) is a quantity that aggregates the effects of variants across the
genome and estimates an individual's genetic predisposition for a given trait. PRS analysis …

Huge technological and biomedical advances have improved the survival and quality of life
of lung cancer patients treated with radiotherapy. However, during treatment planning, a …