Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and
proliferation. The uptake of nutrients from the environment and their intracellular metabolism …

Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master
regulator of cell growth and metabolism, forms two structurally and functionally distinct …

The core symptoms of many neurological disorders have traditionally been thought to be
caused by genetic variants affecting brain development and function. However, the gut …

Epilepsy is a neurological disorder that poses a major threat to public health.
Hyperactivation of mTOR complex 1 (mTORC1) is believed to lead to abnormal network …

Mutations that inactivate negative translation regulators cause autism spectrum disorders
(ASD), which predominantly affect males and exhibit social interaction and communication …

Autism spectrum disorders (ASD) are serious, highly variable neurodevelopmental
disorders, commonly characterized by the manifestation of specific behavioral abnormalities …

The mechanistic target of rapamycin (mTOR) is a kinase at the center of an evolutionarily
conserved signaling pathway that orchestrates cell growth and metabolism. mTOR responds …

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a negative
regulator of AKT/mTOR signaling pathway. Mutations in PTEN are found in patients with …

Brain somatic mutations in various components of the mTOR complex 1 (mTORC1) pathway
have emerged as major causes of focal malformations of cortical development and …