Natural and synthetic coumarins have been extensively described in the literature as
effective drugs with several pharmacological activities. Many valuable publications have …

Background Coumarins, abundantly distributed in a plethora of biologically active
compounds, serve as a fundamental motif in numerous natural products, drugs, and …

Bacterial infections are very common and represent one of the most important reasons of
progression of liver failure, development of liver-related complications, and mortality in …

The inflammasomes are cytoplasmic multiprotein complexes that are responsible for
activation of inflammatory reactions. In principle, there are four individual inflammasome …

Sepsis caused by infection is one of the most important problems of clinical medicine. This
study aimed to determine the effect of Apilarnil (API), a bee product, on lipopolysaccharide …

An extensive network of regulation of systemic inflammation makes development of a
reproducible experimental model of sepsis a complex task. There is no single mouse model …

Liver macrophages make up the largest proportion of tissue macrophages in the host and
consist of two dissimilar groups: Kupffer cells (KCs) and monocyte‑derived macrophages …

Chronic liver diseases, eg, cholestasis, are negatively impacted by inflammation, which
further aggravates liver injury. Pharmacotherapy targeting the peroxisome proliferator …

Background Probiotics play an important role in the human and animal defense against liver
damage. However, the protective mechanism of Lactobacillus plantarum C88 on chronic …

Fulminant hepatitis (FH) is a severe liver disease characterized by extensive hepatic
necrosis, oxidative stress, and inflammation. Myricetin (Myr), a botanical flavonoid glycoside …