Physics of base-pairing dynamics in DNA

M Manghi, N Destainville - Physics Reports, 2016 - Elsevier
As a key molecule of life, Deoxyribo-Nucleic Acid (DNA) is the focus of numbers of
investigations with the help of biological, chemical and physical techniques. From a physical …

Influence of Environmental Parameters on the Stability of the DNA Molecule

A Svidlov, M Drobotenko, A Basov, E Gerasimenko… - Entropy, 2021 - mdpi.com
Fluctuations in viscosity within the cell nucleus have wide limits. When a DNA molecule
passes from the region of high viscosity values to the region of low values, open states …

Thermodynamics of twisted DNA with solvent interaction

M Zoli - The Journal of chemical physics, 2011 - pubs.aip.org
The imaginary time path integral formalism is applied to a nonlinear Hamiltonian for a short
fragment of heterogeneous DNA with a stabilizing solvent interaction term. Torsional effects …

Probing DNA conformational changes with high temporal resolution by tethered particle motion

M Manghi, C Tardin, J Baglio, P Rousseau… - Physical …, 2010 - iopscience.iop.org
The tethered particle motion (TPM) technique informs about conformational changes of DNA
molecules, eg upon looping or interaction with proteins, by tracking the Brownian motion of a …

[HTML][HTML] Thermal properties of a DNA denaturation with solvent interaction

DX Macedo, I Guedes, EL Albuquerque - Physica A: Statistical Mechanics …, 2014 - Elsevier
In this work we study the effects of the solvent interaction on the nonlinear dynamical
structure of a DNA segment, by using a time-independent perturbation approach …

Denaturation patterns in heterogeneous DNA

M Zoli - Physical Review E—Statistical, Nonlinear, and Soft …, 2010 - APS
The thermodynamical properties of heterogeneous DNA sequences are computed by path-
integral techniques applied to a nonlinear model Hamiltonian. The base pairs relative …

Thermal denaturation of fluctuating finite DNA chains: the role of bending rigidity in bubble nucleation

J Palmeri, M Manghi, N Destainville - … E—Statistical, Nonlinear, and Soft Matter …, 2008 - APS
Statistical DNA models available in the literature are often effective models where the base-
pair state only (unbroken or broken) is considered. Because of a decrease by a factor of 30 …

Anharmonic stacking in supercoiled DNA

M Zoli - Journal of Physics: Condensed Matter, 2012 - iopscience.iop.org
Multistep denaturation in a short circular DNA molecule is analyzed by a mesoscopic
Hamiltonian model which accounts for the helicoidal geometry. Computation of melting …

Microscopic mechanism for experimentally observed anomalous elasticity of DNA in two dimensions

N Destainville, M Manghi, J Palmeri - Biophysical journal, 2009 - cell.com
By exploring a recent model in which DNA bending elasticity, described by the wormlike
chain model, is coupled to basepair denaturation, we demonstrate that small denaturation …

Slow closure of denaturation bubbles in DNA: Twist matters

AK Dasanna, N Destainville, J Palmeri… - Physical Review E …, 2013 - APS
The closure of long equilibrated denaturation bubbles in DNA is studied using Brownian
dynamics simulations. A minimal mesoscopic model is used where the double helix is made …