In recent decades, mass spectrometry has moved more than ever before into the front line of
protein-centered research. After being established at the qualitative level, the more …

Over the last few decades, mass spectrometry‐based proteomics has become an
increasingly powerful tool that is now able to routinely detect and quantify thousands of …

Mass spectrometry plays a key role in relative quantitative comparisons of proteins in order
to understand their functional role in biological systems upon perturbation. In this review, we …

The design and synthesis of a proline-based reporter isobaric Tandem Mass Tag structure
(TMTpro) is presented. An analysis is made of the performance of the new TMTpro tags in …

Quantitative mass spectrometry methods offer near-comprehensive proteome coverage;
however, these methods still suffer with regards to sample throughput. Multiplex quantitation …

In the past decade, relative proteomic quantification using isobaric labeling technology has
developed into a key tool for comparing the expression of proteins in biological samples …

Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …

Mass spectrometry (MS) has emerged at the forefront of quantitative proteomic techniques.
Liquid chromatography‐mass spectrometry (LC‐MS) can be used to determine abundances …

Mass spectrometry–based quantitative proteomics is a powerful tool for gaining insights into
function and dynamics of biological systems. However, peptides with different sequences …

Metabolomics and exposomics are important in the studies of human health and diseases.
Chemical isotope labeling (CIL) combined with mass spectrometry (MS) can not only …