The screening of biological samples for the presence of illicit or legal substances is an
important frontline tool in both clinical and forensic toxicology. In the clinical setting, drug …

Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-Tof-MS)
has recently become a popular and versatile method to analyze macromolecules from …

Serum proteins may often serve as indicators of disease and is a rich source for biomarker
discovery. However, the large dynamic range of proteins in serum makes the analysis very …

Objective: Pathological changes in an organ or tissue may be reflected in proteomic patterns
in serum. It is possible that unique serum proteomic patterns could be used to discriminate …

Liver cancer is the fifth most common cancer, but the second leading cause of cancer death,
in the world, with more than 700,000 fatalities annually. The major etiology of liver cancer is …

Background: Detection of hepatocellular carcinoma (HCC) in patients with chronic liver
disease (CLD) is difficult. We investigated the use of comprehensive proteomic profiling of …

Proteomic technologies are being used to discover and identify disease‐associated
biomarkers. The application of these technologies in the search for potential …

The molecular analysis of serum is an important field for the definition of potential diagnostic
markers or disease-related protein alterations. Novel proteomic technologies such as the …

The on-line coupling of capillary electrophoresis (CE) with electrospray-time-of-flight mass
spectrometry (MS) has been used to obtain patterns of peptides and proteins present in the …

Background: Most noninvasive predictive models of liver fibrosis are complicated and have
suboptimal sensitivity. This study was designed to identify serum proteomic signatures …