Abstract Systems Bioinformatics is a relatively new approach, which lies in the intersection of
systems biology and classical bioinformatics. It focuses on integrating information across …

Over the past couple of decades, the explosion of densely interconnected data has
stimulated the research, development and adoption of graph database technologies. From …

Reactome is a free, open-source, open-data, curated and peer-reviewed knowledgebase of
biomolecular pathways. One of its main priorities is to provide easy and efficient access to its …

At the heart of the cellular machinery through the regulation of cellular functions, protein–
protein interactions (PPIs) have a significant role. PPIs can be analyzed with network …

Cellular regulation is inherently complex, and one particular cellular function is often
controlled by a cascade of different types of regulatory interactions. For example, the activity …

Aims The metabolic syndrome and associated comorbidities, like diabetes, hypertension
and obesity, have been implicated in the development of heart failure with preserved …

The speed and accuracy of new scientific discoveries–be it by humans or artificial
intelligence–depends on the quality of the underlying data and on the technology to …

Aims Myocardial fibrosis alters the cardiac architecture favouring the development of cardiac
dysfunction, including arrhythmias and heart failure. Reducing myocardial fibrosis may …

Mako is a software tool that converts microbiome data and networks into a graph database
and visualizes query results, thus allowing users without programming knowledge to carry …

Aims End-stage renal disease (ESRD) treated by chronic hemodialysis (HD) is associated
with poor cardiovascular (CV) outcomes, with no available evidence-based therapeutics. A …