Reagents and models for detecting endogenous GLP1R and GIPR
Abstract Glucagon-like peptide-1 receptor (GLP1R) agonists target the GLP1R, whereas
dual GLP1R/gastric inhibitory polypeptide receptor (GIPR) agonists target both the GLP1R …
dual GLP1R/gastric inhibitory polypeptide receptor (GIPR) agonists target both the GLP1R …
Emerging modes of regulation of neuromodulatory G protein-coupled receptors
In the nervous system, G protein-coupled receptors (GPCRs) control neuronal excitability,
synaptic transmission, synaptic plasticity, and, ultimately, behavior through spatiotemporally …
synaptic transmission, synaptic plasticity, and, ultimately, behavior through spatiotemporally …
N-Methyl deuterated rhodamines for protein labelling in sensitive fluorescence microscopy
Rhodamine fluorophores are setting benchmarks in fluorescence microscopy. Herein, we
report the deuterium (d12) congeners of tetramethyl (silicon) rhodamine, obtained by …
report the deuterium (d12) congeners of tetramethyl (silicon) rhodamine, obtained by …
Revealing the tissue-level complexity of endogenous glucagon-like peptide-1 receptor expression and signaling
The glucagon-like peptide-1 receptor (GLP1R) is a class BG protein-coupled receptor
(GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are …
(GPCR) involved in glucose homeostasis and food intake. GLP1R agonists (GLP1RA) are …
DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling
CE Stieger, Y Park, MAR de Geus… - Angewandte Chemie …, 2022 - Wiley Online Library
We report the density functional theory (DFT) guided discovery of ethynyl‐triazolyl‐
phosphinates (ETPs) as a new class of electrophilic warheads for cysteine selective …
phosphinates (ETPs) as a new class of electrophilic warheads for cysteine selective …
Peptide-coated polycaprolactone-benzalkonium chloride nanocapsules for targeted drug delivery to the pancreatic β-cell
Targeting current therapies to treat or prevent the loss of pancreatic islet β-cells in Type 1
Diabetes (T1D) may provide improved efficacy and reduce off-target effects. Current efforts …
Diabetes (T1D) may provide improved efficacy and reduce off-target effects. Current efforts …
[HTML][HTML] GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells
Abstract Glucagon-like peptide-1 receptor (GLP1R) and glucose-dependent insulinotropic
polypeptide receptor (GIPR) are transmembrane receptors involved in insulin, glucagon and …
polypeptide receptor (GIPR) are transmembrane receptors involved in insulin, glucagon and …
Multicolor, Cell-Impermeable, and High Affinity BACE1 Inhibitor Probes Enable Superior Endogenous Staining and Imaging of Single Molecules
F Stockinger, P Poc, A Möhwald, S Karch… - Journal of Medicinal …, 2024 - ACS Publications
The prevailing but not undisputed amyloid cascade hypothesis places the β-site of APP
cleaving enzyme 1 (BACE1) center stage in Alzheimer′ s Disease pathogenesis. Here, we …
cleaving enzyme 1 (BACE1) center stage in Alzheimer′ s Disease pathogenesis. Here, we …
DFT‐basierte Entdeckung von Ethynyl‐Triazolyl‐Phosphinaten als modulare Elektrophile für die chemoselektive Cystein‐Biokonjugation und Profilierung
CE Stieger, Y Park, MAR de Geus, D Kim… - Angewandte …, 2022 - Wiley Online Library
Wir berichten über eine Dichtefunktionaltheorie (DFT)‐basierte Entdeckung von Ethinyl‐
Triazolyl‐Phosphinaten (ETP) als eine neue Klasse elektrophiler Verbindungen für die …
Triazolyl‐Phosphinaten (ETP) als eine neue Klasse elektrophiler Verbindungen für die …
Dynamic regulation of pancreatic β cell function and gene expression by the SND1 coregulator in vitro
S Kanojia, RK Davidson, JM Conley, J Xu, M Osmulski… - Islets, 2023 - Taylor & Francis
The pancreatic β cell synthesizes, packages, and secretes insulin in response to glucose-
stimulation to maintain blood glucose homeostasis. Under diabetic conditions, a subset of β …
stimulation to maintain blood glucose homeostasis. Under diabetic conditions, a subset of β …