Protein aggregation and neurodegenerative diseases: From theory to therapy
The study of protein misfolding and aggregation saw resurgence in the last decade.
Aggregation is the main cause of several human neurodegenerative diseases which makes …
Aggregation is the main cause of several human neurodegenerative diseases which makes …
Conditions governing food protein amyloid fibril formation—Part I: Egg and cereal proteins
KJA Jansens, MA Lambrecht… - … reviews in food …, 2019 - Wiley Online Library
Conditions including heating mode, time, temperature, pH, moisture and protein
concentration, shear, and the presence of alcohols, chaotropic/reducing agents, enzymes …
concentration, shear, and the presence of alcohols, chaotropic/reducing agents, enzymes …
Functionalisation of polyvinylpyrrolidone on gold nanoparticles enhances its anti-amyloidogenic propensity towards hen egg white lysozyme
Protein amyloids are characterized by aggregates that usually consist of fibres containing
misfolded proteins and having a cross β-sheet conformation. These aggregates can …
misfolded proteins and having a cross β-sheet conformation. These aggregates can …
Lanosterol suppresses the aggregation and cytotoxicity of misfolded proteins linked with neurodegenerative diseases
Accumulation of misfolded or aberrant proteins in neuronal cells is linked with
neurodegeneration and other pathologies. Which molecular mechanisms fail and cause …
neurodegeneration and other pathologies. Which molecular mechanisms fail and cause …
Proline functionalized gold nanoparticles modulates lysozyme fibrillation
Amyloid fibrils are the hallmarks of neurodegenerative diseases like Alzheimer's,
Parkinson's and other proteopathies. Inhibition of fibrillation is a potential strategy to check …
Parkinson's and other proteopathies. Inhibition of fibrillation is a potential strategy to check …
Biophysical insights into the interaction of hen egg white lysozyme with therapeutic dye clofazimine: modulation of activity and SDS induced aggregation of model …
The present study details the binding process of clofazimine to hen egg white lysozyme
(HEWL) using spectroscopy, dynamic light scattering, transmission electron microscopy …
(HEWL) using spectroscopy, dynamic light scattering, transmission electron microscopy …
Inhibition of amyloid fibril formation and disassembly of pre-formed fibrils by natural polyphenol rottlerin
K Siposova, T Kozar, V Huntosova, S Tomkova… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Natural polyphenols, curcumin, rottlerin and EGCG were selected for initial computational
modeling of protein-ligand interaction patterns. The docking calculations demonstrated that …
modeling of protein-ligand interaction patterns. The docking calculations demonstrated that …
Binding of glyco-acridine derivatives to lysozyme leads to inhibition of amyloid fibrillization
While amyloid-related diseases are at the center of intense research efforts, no feasible cure
is currently available for these diseases. The experimental and computational techniques …
is currently available for these diseases. The experimental and computational techniques …
[HTML][HTML] Extending the investigation of 4-thiazolidinone derivatives as potential multi-target ligands of enzymes involved in diabetes mellitus and its long-term …
Diabetes mellitus is a multifactorial disease, which is frequently complicated by the
development of hyperglycaemia-induced chronic complications. The therapy of diabetes …
development of hyperglycaemia-induced chronic complications. The therapy of diabetes …
Rottlerin and curcumin: a comparative analysis
E Maioli, C Torricelli, G Valacchi - … of the New York Academy of …, 2012 - Wiley Online Library
Rottlerin and curcumin are natural plant polyphenols with a long tradition in folk medicine.
Over the past two decades, curcumin has been extensively investigated, while rottlerin has …
Over the past two decades, curcumin has been extensively investigated, while rottlerin has …