There is increasing evidence that cardiovascular control during sleep is relevant for
cardiovascular risk. This evidence warrants increased experimental efforts to understand the …

Orexins (OX-A and OX-B), also referred to as hypocretin 1 and 2, are neuropeptides
synthesized by neurons located in the perifornical and lateral regions of the hypothalamus …

The central neural pathways underlying the physiological coordination between
thermoregulation and the controls of the wake-sleep behavior and cardiovascular function …

The upright posture strengthens the coupling between heart period (HP) and systolic arterial
pressure (SAP) consistently with a greater contribution of the arterial baroreflex to cardiac …

Narcolepsy is a rare disease that entails excessive daytime sleepiness, often associated
with sudden episodes of muscle weakness known as cataplexy. Narcolepsy with cataplexy …

Hypocretin/orexin signalling varies among sleep–wake behaviours, impacts upon
cardiovascular autonomic control and is impaired in patients with narcolepsy with cataplexy …

Abstract Study Objectives Increase in arterial pressure (AP) during sleep and smaller
differences in AP between sleep and wakefulness have been reported in orexin (hypocretin) …

Narcolepsy with cataplexy (NC) is a lifelong disorder caused by loss of hypothalamic
hypocretin/orexin (HCRT) neurones, often starting in childhood. NC patients show altered …

This article advances the theory that the hypocretinergic (orexinergic) system initiates,
coordinates, and maintains survival behaviors and survival-related processes (ie, the …

Mammals typically display alternating active and resting phases and, in most species, these
rhythms follow a circadian pattern. The active and resting phases often are accompanied by …