Microglia, the immunocompetent cells of the central nervous system (CNS), act as
neuropathology sensors and are neuroprotective under physiological conditions. Microglia …

Retinal remodeling is a progressive series of negative plasticity revisions that arise from
retinal degeneration, and are seen in retinitis pigmentosa, age-related macular …

Background: PD patients often have visual alterations, for example, loss of visual acuity,
contrast sensitivity or motion perception, and diminished electroretinogram responses. PD …

Despite decades of research, accurate diagnosis of Parkinson's disease remains a
challenge, and disease-modifying treatments are still lacking. Research into the early …

With increasing age, structural changes occur in the eye and brain. Neuronal death,
inflammation, vascular disruption, and microglial activation are among many of the …

Mouse models of retinal degeneration are useful tools to study therapeutic approaches for
patients affected by hereditary retinal dystrophies. We have studied degeneration in the rd10 …

There is increasing interest in studying retinal biomarkers for various neurodegenerative
diseases. Specific protein aggregates associated with neurodegenerative diseases are …

Visual symptoms are relatively common in Parkinson's disease (PD) and optical coherence
tomography has indicated possible retinal thinning. Accumulation of aggregated α-synuclein …

Visual disorder is one of the non-motor symptoms found in Parkinson's disease (PD). It can
be easily identified in the early stages even before the spread of pathological conditions to …

Parkinson's disease (PD) is characterized by motor dysfunctions including bradykinesia,
tremor at rest and motor instability. These symptoms are associated with the progressive …