Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although
the role of DNA methylation at gene promoters and repetitive elements has been extensively …

The field of 3D genome organization produces large amounts of sequencing data from Hi-C
and a rapidly-expanding set of other chromosome conformation protocols (3C+). Massive …

TAD boundaries are genomic elements that separate biological processes in neighboring
domains by blocking DNA loops that are formed through Cohesin‐mediated loop extrusion …

The specificity of gene expression during development requires the insulation of regulatory
domains to avoid inappropriate enhancer-gene interactions. In vertebrates, this insulator …

During mammalian embryogenesis, both the 5-cytosine DNA methylation (5meC) landscape
and three dimensional (3D) chromatin architecture are profoundly remodeled during a …

While the elements encoding enhancers and promoters have been relatively well studied,
the full spectrum of insulator elements which bind the CCCTC binding factor (CTCF), is …

Long-range transcriptional activation of gene promoters by abundant enhancers in animal
genomes calls for mechanisms to limit inappropriate regulation. DNA elements called …

Interphase mammalian genomes are folded in 3D with complex locus-specific patterns that
impact gene regulation. CTCF (CCCTC-binding factor) is a key architectural protein that …

Background An intergenic region at chromosome 4q31 is one of the most significant regions
associated with COPD susceptibility and lung function in GWAS. In this region, the …

The specificity of gene expression during development requires the insulation of regulatory
domains to avoid inappropriate enhancer-gene interactions. In vertebrates, this insulator …