Molecular mechanisms of iron and heme metabolism

S Dutt, I Hamza, TB Bartnikas - Annual review of nutrition, 2022 - annualreviews.org
An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

The concept of folic acid in health and disease

Y Shulpekova, V Nechaev, S Kardasheva, A Sedova… - Molecules, 2021 - mdpi.com
Folates have a pterine core structure and high metabolic activity due to their ability to accept
electrons and react with O-, S-, N-, C-bounds. Folates play a role as cofactors in essential …

The role of iron in host–microbiota crosstalk and its effects on systemic glucose metabolism

J Mayneris-Perxachs, JM Moreno-Navarrete… - Nature Reviews …, 2022 - nature.com
Iron is critical for the appearance and maintenance of life on Earth. Almost all organisms
compete or cooperate for iron acquisition, demonstrating the importance of this essential …

A short review of iron metabolism and pathophysiology of iron disorders

A Yiannikourides, GO Latunde-Dada - Medicines, 2019 - mdpi.com
Iron is a vital trace element for humans, as it plays a crucial role in oxygen transport,
oxidative metabolism, cellular proliferation, and many catalytic reactions. To be beneficial …

[HTML][HTML] Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health

Z Wan, J Zheng, Z Zhu, L Sang, J Zhu, S Luo… - Frontiers in …, 2022 - frontiersin.org
Vitamin B consists of a group of water-soluble micronutrients that are mainly derived from
the daily diet. They serve as cofactors, mediating multiple metabolic pathways in humans. As …

Functional roles of B‐vitamins in the gut and gut microbiome

T Uebanso, T Shimohata, K Mawatari… - Molecular nutrition & …, 2020 - Wiley Online Library
The gut microbiota produce hundreds of bioactive compounds, including B‐vitamins, which
play significant physiological roles in hosts by supporting the fitness of symbiotic species …

Gut microbiota and iron: the crucial actors in health and disease

B Yilmaz, H Li - Pharmaceuticals, 2018 - mdpi.com
Iron (Fe) is a highly ample metal on planet earth (~ 35% of the Earth's mass) and is
particularly essential for most life forms, including from bacteria to mammals. Nonetheless …

Systemic iron homeostasis

T Ganz - Physiological reviews, 2013 - journals.physiology.org
The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …

[HTML][HTML] Biomarkers of nutrition for development—folate review

LB Bailey, PJ Stover, H McNulty, MF Fenech… - The Journal of …, 2015 - Elsevier
Abstract The Biomarkers of Nutrition for Development (BOND) project is designed to provide
evidence-based advice to anyone with an interest in the role of nutrition in health …

Structural basis for molecular recognition of folic acid by folate receptors

C Chen, J Ke, XE Zhou, W Yi, JS Brunzelle, J Li… - Nature, 2013 - nature.com
Folate receptors (FRα, FRβ and FRγ) are cysteine-rich cell-surface glycoproteins that bind
folate with high affinity to mediate cellular uptake of folate. Although expressed at very low …