Types of nuclear localization signals and mechanisms of protein import into the nucleus

J Lu, T Wu, B Zhang, S Liu, W Song, J Qiao… - Cell communication and …, 2021 - Springer
Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment
that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS …

Intrinsically disordered proteins: an overview

R Trivedi, HA Nagarajaram - International journal of molecular sciences, 2022 - mdpi.com
Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

Mechanical force application to the nucleus regulates nucleocytoplasmic transport

I Andreu, I Granero-Moya, NR Chahare, K Clein… - Nature cell …, 2022 - nature.com
Mechanical force controls fundamental cellular processes in health and disease, and
increasing evidence shows that the nucleus both experiences and senses applied forces …

Compositional control of phase-separated cellular bodies

SF Banani, AM Rice, WB Peeples, Y Lin, S Jain… - Cell, 2016 - cell.com
Cellular bodies such as P bodies and PML nuclear bodies (PML NBs) appear to be phase-
separated liquids organized by multivalent interactions among proteins and RNA molecules …

Classification of intrinsically disordered regions and proteins

R Van Der Lee, M Buljan, B Lang, RJ Weatheritt… - Chemical …, 2014 - ACS Publications
Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes

FK Fordjour, C Guo, Y Ai, GG Daaboul… - Journal of Biological …, 2022 - ASBMB
Exosomes are small extracellular vesicles of∼ 30 to 150 nm that are secreted by all cells,
abundant in all biofluids, and play important roles in health and disease. However, details …

ELM—the Eukaryotic Linear Motif resource—2024 update

M Kumar, S Michael, J Alvarado-Valverde… - Nucleic acids …, 2024 - academic.oup.com
Abstract Short Linear Motifs (SLiMs) are the smallest structural and functional components of
modular eukaryotic proteins. They are also the most abundant, especially when considering …

Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells

I Kwon, S Xiang, M Kato, L Wu, P Theodoropoulos… - Science, 2014 - science.org
Many RNA regulatory proteins controlling pre–messenger RNA splicing contain serine:
arginine (SR) repeats. Here, we found that these SR domains bound hydrogel droplets …

Cell penetrating peptides as molecular carriers for anti-cancer agents

A Borrelli, AL Tornesello, ML Tornesello… - Molecules, 2018 - mdpi.com
Cell membranes with their selective permeability play important functions in the tight control
of molecular exchanges between the cytosol and the extracellular environment as the …

Light-induced collective pseudospin precession resonating with Higgs mode in a superconductor

R Matsunaga, N Tsuji, H Fujita, A Sugioka, K Makise… - Science, 2014 - science.org
Superconductors host collective modes that can be manipulated with light. We show that a
strong terahertz light field can induce oscillations of the superconducting order parameter in …