Brown and beige adipocytes are mitochondria-enriched cells capable of dissipating energy
in the form of heat. These thermogenic fat cells were originally considered to function solely …

The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Brown adipose tissue (BAT) is the main site of adaptive thermogenesis and experimental
studies have associated BAT activity with protection against obesity and metabolic diseases …

Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …

Many of the comorbidities of obesity, including type 2 diabetes and cardiovascular diseases,
are related to the low‐grade chronic inflammation of white adipose tissue. Under white …

Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to
obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of …

Beiging of white adipose tissue (WAT) is associated with an increase of anti-inflammatory
M2-like macrophages in WAT. However, mechanisms through which M2-like macrophages …

Immune cells were recently found to have an unexpected involvement in controlling the
thermogenic activity of brown and beige adipose tissue. Here, we review how macrophages …

Metabolic inflammation is closely linked to obesity, and is implicated in the pathogenesis of
metabolic diseases. FTO harbors the strongest genetic association with polygenic obesity …

Signaling pathways that promote adipose tissue thermogenesis are well characterized, but
the limiters of energy expenditure are largely unknown. Here, we show that ablation of the …