In 2012, researchers proposed a non-apoptotic, iron-dependent form of cell death caused by
lipid peroxidation called ferroptosis. During the past decade, a comprehensive …

The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental
signaling event that plays a critical role in regulating tissue development and maintaining …

Acute kidney injury (AKI) is a major kidney disease associated with poor clinical outcomes.
Oxidative stress is predominantly involved in the pathogenesis of AKI. Autophagy and the …

Background: Limited previous studies in the United Kingdom or a single US state have
demonstrated an association between intake of glucosamine/chondroitin and mortality. This …

Background/Aims: The clinical utility of 5-fluorouracil (5-FU) is limited by its nephrotoxicity.
Camel milk (CM) has previously displayed beneficial effects in toxicant-induced …

Multifaceted cellular pathways exhibit a crucial role in the preservation of homeostasis at the
molecular, cellular, and organism levels. One of the most important of these protective …

Reactive oxygen species (ROS) carry out prime physiological roles as intracellular signaling
agents, yet pathologically high concentrations of ROS cause irreversible damage to …

Acute kidney injury (AKI) is a clinical syndrome that results from a rapid decline in renal
structure or renal functional impairment with the main pathological feature of sublethal and …

Ischemia reperfusion injury (IR injury) associated with ischemic heart disease contributes
significantly to morbidity and mortality. O-linked β-N-acetylglucosamine (O-GlcNAc) is a …

Methotrexate (MTX) is a classical chemotherapeutic agent with nephrotoxicity as the most
disturbing adverse effect. So far, its underlying molecular mechanisms, particularly …