Epidemiology of stroke in sickle cell disease

FJ Kirkham, IA Lagunju - Journal of Clinical Medicine, 2021 - mdpi.com
Sickle cell disease is the most common cause of stroke in childhood, both ischaemic and
haemorrhagic, and it also affects adults with the condition. Without any screening or …

Genetic variation and sickle cell disease severity: a systematic review and meta-analysis

JK Kirkham, JH Estepp, MJ Weiss… - JAMA network …, 2023 - jamanetwork.com
Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Genetic Modifiers of Stroke in Patients with Sickle Cell Disease—A Scoping Review

MO Oni, M Brito, C Rotman, NM Archer - International Journal of …, 2024 - mdpi.com
Sickle cell disease (SCD) clinically manifests itself with a myriad of complications. Stroke,
both ischemic and hemorrhagic, as well as silent white matter changes, occurs at a relatively …

Genetic Variants Associated with the Risk of Stroke in Sickle Cell Anemia: Systematic Review and Meta-Analysis

A Kumari, G Chauhan, PK Chaudhuri, S Kumari… - …, 2024 - Taylor & Francis
Sickle cell anemia (SCA) is the most common cause of stroke in children. As it is a rare
disease, studies investigating the association with complications like stroke in SCD have …

Interplay between α‐thalassemia and β‐hemoglobinopathies: Translating genotype–phenotype relationships into therapies

J Vadolas, T Nualkaew, HPJ Voon, S Vilcassim… - …, 2024 - Wiley Online Library
Abstract α‐Thalassemia represents one of the most important genetic modulators of β‐
hemoglobinopathies. During this last decade, the ongoing interest in characterizing …

Genetic variants associated with the risk of stroke in sickle cell disease: a systematic review and meta-analysis

A Kumari, G Chauhan, PK Chaudhuri, A Prasad - medRxiv, 2023 - medrxiv.org
Background: Sickle cell disease (SCD) is the commonest cause of stroke in children. As it is
a rare disease, studies investigating the association with complications like stroke in SCD …

Neurocognitive Complications of Sickle Cell Disease in Africa

F Kirkham, M Ampomah, M Jacob… - Sickle Cell Disease in …, 2024 - taylorfrancis.com
Acute neurological complications are common in sickle cell disease (SCD) and include, in
addition to central nervous system infections, ischaemic stroke, typically presenting as …

Correlation of beta-globin haplotypes with the clinical complications and alterations in circulating hematopoietic stem and progenitor cells with the use of hydroxyurea …

JMS Lima - 2024 - teses.usp.br
Sickle cell anemia (SCA) is a hereditary disorder characterized by abnormal hemoglobin
production, leading to the formation of sickle-shaped red blood cells. This genetic mutation …

[引用][C] Investigação da associação de polimorfismos no gene selp e dos níveis plasmáticos da SP-selectina com complicações clínicas de pacientes com anemia …

RN BERNARDO - 2024 - Universidade Federal de …