Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Highlights•Evaluating drug efficacy, specificity and toxicity may help to develop an optimal
treatment regime for in vivo studies.•Measuring time to resolve viremia in vivo may help to …

Iminosugars comprise the most attractive class of carbohydrate mimetics reported to date
and are ideally positioned to take advantage of our increasing understanding of …

The Flavivirus genus contains many important human pathogens, including dengue,
Japanese encephalitis (JE), tick-borne encephalitis (TBE), West Nile (WN), yellow fever (YF) …

The dengue virus and related flaviviruses are an increasing global health threat. In this
perspective, we comment on and review medicinal chemistry efforts aimed at the prevention …

The flavivirus non-structural protein, NS1, is an unusual viral gene product. Despite the
recent unveiling of its atomic structure (Akey et al., 2014), and a growing list of host …

Dengue virus and other flaviviruses such as the yellow fever, West Nile, and Japanese
encephalitis viruses are emerging vector‐borne human pathogens that affect annually more …

Dengue virus (DENV) is an emerging mosquito-borne human pathogen that affects millions
of individuals each year by causing severe and potentially fatal syndromes. Despite intense …

The level of cholesterol in host cells has been shown to affect viral infection. However, it is
still not understood why this level of regulation is important for successful infection. We have …

Endoplasmic reticulum (ER)-resident α-glucosidases I and II sequentially trim the three
terminal glucose moieties on N-linked glycans attached to nascent glycoproteins. These …