Antimalarial drugs (AD) are a group of widespread therapeutic agents in multiple rheumatic
indications. Although the effect of AD is mild and extended in time, low toxicity is their …

In order to resorb the mineralized bone extracellular matrix, the osteoclast relies on the
generation of a resorption lacuna characterized by the presence of specific proteases and a …

The cytokines RANKL and TNF activate NF-κB signaling in osteoclast precursors (OCPs) to
induce osteoclast (OC) formation. Conversely, TNF can limit OC formation through NF-κB …

Osteoclasts are highly differentiated terminal cells formed by fusion of hematopoietic stem
cells. Previously, osteoprotegerin (OPG) inhibit osteoclast differentiation and bone …

As one of the most toxic heavy metals in the environment, cadmium (Cd) poses a severe
threat to plant growth. We previously reported that overexpression of the Tamarix hispida V …

This review focuses on one of the 16 proteins composing the V-ATPase complex
responsible for resorbing bone: the a 3 subunit. The rationale for focusing on this …

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase involved in the
regulation of cell growth. It has been shown to play an important role in osteoclast …

Abstract Vacuolar-type ATPase (V-ATPase) shares its structure and rotational catalysis with
F-type ATPase (F-ATPase, ATP synthase). However, unlike subunits of F-ATPase, those of V …

As wear particles-induced osteolysis still remains the leading cause of early implant
loosening in endoprosthetic surgery, and promotion of osteoclastogenesis by wear particles …

ABSTRACT Vacuolar‐type H+‐ATPases (V‐ATPases) are located in lysosomes and at the
ruffled border in osteoclasts. We showed previously that the R740S mutation is dominant …