Lotus (Nelumbo nucifera Gaertn.) and Its Bioactive Phytocompounds: A Tribute to Cancer Prevention and Intervention

A Bishayee, PA Patel, P Sharma, S Thoutireddy, N Das - Cancers, 2022 - mdpi.com
Simple Summary The plant Nelumbo nucifera (Gaertn.), commonly known as lotus, sacred
lotus, Indian lotus, water lily, or Chinese water lily, is an aquatic perennial crop belonging to …

An updated review on pharmacological properties of neferine—A bisbenzylisoquinoline alkaloid from Nelumbo nucifera

L Bharathi Priya, CY Huang, RM Hu… - Journal of Food …, 2021 - Wiley Online Library
Phytochemicals have recently received a lot of recognition for their pharmacological
activities such as anticancer, chemopreventive, and cardioprotective properties. In traditional …

Pharmacological benefits of neferine-A comprehensive review

SM Asokan, R Mariappan, S Muthusamy… - Life sciences, 2018 - Elsevier
This article recapitulates the existing in vitro and in vivo studies focusing on the effects of
neferine-an alkaloid derivative of lotus plant, in various disease models and its effects on …

Bisbenzylisoquinoline alkaloids

C Weber, T Opatz - The Alkaloids: Chemistry and Biology, 2019 - Elsevier
The present review covers the literature on bisbenzylisoquinoline alkaloids from 1999
through early 2018. About 500 natural products belong to this large alkaloid class, of which …

Neferine, an alkaloid from lotus seed embryos, exerts antiseizure and neuroprotective effects in a kainic acid-induced seizure model in rats

TY Lin, CY Hung, KM Chiu, MY Lee, CW Lu… - International Journal of …, 2022 - mdpi.com
Current anti-seizure drugs fail to control approximately 30% of epilepsies. Therefore, there is
a need to develop more effective anti-seizure drugs, and medicinal plants provide an …

Neferine, a bisbenzylisoquinline alkaloid attenuates bleomycin-induced pulmonary fibrosis

L Zhao, X Wang, Q Chang, J Xu, Y Huang… - European journal of …, 2010 - Elsevier
In this study, we evaluated the potential anti-fibrotic property of neferine, a
bisbenzylisoquinline alkaloid extracted from the seed embryo of Nelumbo mucifera Gaertn …

Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest

P Poornima, CF Weng, VV Padma - Biofactors, 2014 - Wiley Online Library
Neferine is the major bisbenzylisoquinoline alkaloid isolated from the seed embryo of a
traditional medicinal plant Nelumbo nucifera (Lotus). Epidemiological studies have revealed …

Neferine induces reactive oxygen species mediated intrinsic pathway of apoptosis in HepG2 cells

P Poornima, RS Quency, VV Padma - Food chemistry, 2013 - Elsevier
Evidence has accumulated concerning the medicinal application of Nelumbo nucifera in the
treatment of various diseases. Neferine, an alkaloid from N. nucifera was found to exert …

Alkaloids from lotus (Nelumbo nucifera): recent advances in biosynthesis, pharmacokinetics, bioactivity, safety, and industrial applications

Z Wang, Y Li, D Ma, M Zeng, Z Wang, F Qin… - Critical Reviews in …, 2023 - Taylor & Francis
Different parts of lotus (Nelumbo nucifera Gaertn.) including the seeds, rhizomes, leaves,
and flowers, are used for medicinal purposes with health promoting and illness preventing …

[HTML][HTML] Neferine ameliorates hypertensive vascular remodeling modulating multiple signaling pathways in spontaneously hypertensive rats

W Zeng, X Zhang, Y Lu, Y Wen, Q Xie, X Yang… - Biomedicine & …, 2023 - Elsevier
Background Neferine exhibits therapeutic effects on anti-hypertension. However, the effect
of neferine on hypertensive vascular remodeling remains unexplored. Therefore, the current …