Pityriasis rubra pilaris (PRP) is an idiopathic, papulosquamous inflammatory dermatosis. It is
characterized by hyperkeratotic follicular papules coalescing into orange-red scaly plaques …

Among the genetic causes/predisposing factors for inflammatory keratinization disorders,
several factors are associated with autoinflammatory mechanisms. Here we review these …

Generalized pustular psoriasis (GPP) is a severe, relapsing, immune-mediated disease
characterized by the presence of multiple sterile pustules all over the body. The exact …

Rare autosomal dominant mutations in the gene encoding the keratinocyte signaling
molecule CARD14, have been associated with an increased susceptibility to psoriasis, but …

Pityriasis rubra pilaris (PRP) is a rare inflammatory skin disease that affects men and women
of all ages and also children. The clinical appearance of PRP is highly variable, as is the …

Generalized pustular psoriasis (GPP) is a chronic, systemic inflammatory disease
accompanied by high fever and general malaise. Diffuse erythema and swelling of the …

Classifying inflammatory skin diseases is challenging, especially for the expanding group of
disorders triggered by genetic factors resulting in hyperactivated innate immunity that result …

The CARD: BCL10: MALT1 (CBM) complex is an essential signaling node for maintaining
both innate and adaptive immune responses. CBM complex components have gained …

Pustular psoriasis is a chronic inflammatory skin disease characterized by erythematous
plaques with sterile pustules. It includes the distinct clinical entities generalized pustular …

Autoinflammatory diseases are characterized by innate immunity abnormalities. In
autoinflammatory diseases (AID), inflammatory blood biomarkers are elevated during crisis …