Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Heme oxygenase-1: an anti-inflammatory effector in cardiovascular, lung, and related metabolic disorders

SW Ryter - Antioxidants, 2022 - mdpi.com
The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

Stimuli‐Responsive antibacterial materials: molecular structures, design principles, and biomedical applications

X Wang, M Shan, S Zhang, X Chen, W Liu… - Advanced …, 2022 - Wiley Online Library
Infections are regarded as the most severe complication associated with human health,
which are urgent to be solved. Stimuli‐responsive materials are appealing therapeutic …

An orally-administered nanotherapeutics with carbon monoxide supplying for inflammatory bowel disease therapy by scavenging oxidative stress and restoring gut …

X Zhang, Z Yuan, J Wu, Y He, G Lu, D Zhang, Y Zhao… - ACS …, 2023 - ACS Publications
Traditional drug-based treatments for inflammatory bowel disease (IBD) have significant
limitations due to their potential off-target systemic side-effects. Currently, there is a lack of …

Mechanically triggered carbon monoxide release with turn-on aggregation-induced emission

Y Sun, WJ Neary, ZP Burke, H Qian… - Journal of the …, 2022 - ACS Publications
Polymers that release functional small molecules under mechanical stress potentially serve
as next-generation materials for catalysis, sensing, and mechanochemical dynamic therapy …

An all-in-one CO gas therapy-based hydrogel dressing with sustained insulin release, anti-oxidative stress, antibacterial, and anti-inflammatory capabilities for infected …

J Chen, D Chen, J Chen, T Shen, T Jin, B Zeng, L Li… - Acta biomaterialia, 2022 - Elsevier
To effectively treat diabetic wounds, the development of versatile medical dressings that can
long-term regulate blood glucose and highly effective anti-oxidative stress, antibacterial and …

Metal complexes for therapeutic applications

J Karges, RW Stokes, SM Cohen - Trends in chemistry, 2021 - cell.com
Metal complexes have been widely used for applications in the chemical and physical
sciences due to their unique electronic and stereochemical properties. For decades the use …

X‐Ray‐triggered Carbon Monoxide and Manganese Dioxide Generation based on Scintillating Nanoparticles for Cascade Cancer Radiosensitization

Z Du, X Wang, X Zhang, Z Gu, X Fu… - Angewandte Chemie …, 2023 - Wiley Online Library
Carbon monoxide (CO) is an endogenous signaling molecule with broad therapeutic effects.
Here, a multifunctional X‐ray‐triggered carbon monoxide (CO) and manganese dioxide …

Near‐Infrared Light‐Activatable Dual‐Action Nanoparticle Combats the Established Biofilms of Methicillin‐Resistant Staphylococcus aureus and Its Accompanying …

Z Yuan, C Lin, L Dai, Y He, J Hu, K Xu, B Tao, P Liu… - Small, 2021 - Wiley Online Library
Clinically, inhibition of both bacterial infection and excessive inflammation is a crucial step
for improved wound treatments. Herein, the fabrication of near‐infrared‐light (NIR) …

Ultra-efficient antibacterial system based on photodynamic therapy and CO gas therapy for synergistic antibacterial and ablation biofilms

W Ma, X Chen, L Fu, J Zhu, M Fan, J Chen… - … applied materials & …, 2020 - ACS Publications
In recent years, with the emergence of various kinds of drug-resistant bacteria, existing
antibiotics have become inefficient in killing these bacteria, and the formation of biofilms has …