Pulmonary functional imaging may be defined as the regional quantification of lung function
by using primarily CT, MRI, and nuclear medicine techniques. The distribution of pulmonary …

Pulmonary functional MRI (PfMRI) using inhaled hyperpolarized, radiation‐free gases (such
as 3He and 129Xe) provides a way to directly visualize inhaled gas distribution and …

Rationale: Loss of the peripheral pulmonary vasculature, termed vascular pruning, is
associated with disease severity in patients with chronic obstructive pulmonary disease …

Background The functional consequence of airway obstruction in asthma can be regionally
measured using inhaled gas MRI. Ventilation defects visualized by MRI persist post …

Respiratory diseases are leading causes of death and disability in the world. While early
diagnosis is key, this has proven difficult due to the lack of sensitive and non-invasive tools …

A number of methods have evolved through the years in probing the dysfunction that
impacts mechanics and ventilation in asthma. What has been consistently found is the …

Asthma is a disease involving both airway remodelling (eg thickening of the airway wall) and
acute, reversible airway narrowing driven by airway smooth muscle contraction. Both of …

Rationale: Regional hypoventilation in bronchoconstricted patients with asthma is spatially
associated with reduced perfusion, which is proposed to result from hypoxic pulmonary …

The role of imaging in severe asthma currently is primarily in the exclusion of comorbid or
other conditions, or in the assessment for complications in the setting of acute …

Purpose To perform magnetic resonance imaging (MRI), human lung imaging, and
quantification of the gas-transfer dynamics of hyperpolarized xenon-129 (HPX) from the …