Oxadiazole: A highly versatile scaffold in drug discovery

N Desai, J Monapara, A Jethawa… - Archiv der …, 2022 - Wiley Online Library
As a pharmacologically important heterocycle, oxadiazole paved the way to combat the
problem associated with the confluence of many commercially available drugs with different …

1, 3, 4-oxadiazole: a biologically active scaffold

H Khalilullah, MJ Ahsan, M Hedaitullah… - Mini reviews in …, 2012 - ingentaconnect.com
There has been considerable interest in the development of novel compounds with
anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiallergic, antipsychotic …

A first-principles evaluation on the interaction of 1, 3, 4-oxadiazole with pristine and B-, Al-, Ga-doped C60 fullerenes

İ Muz, M Kurban - Journal of Molecular Liquids, 2021 - Elsevier
In this study, the interaction of 1, 3, 4-oxadiazole with pristine and B-, Al-, Ga-doped C 60
fullerenes were examined by density functional theory (DFT) for the first time. The results …

Updates on synthesis and biological activities of 1, 3, 4-oxadiazole: A review

Salahuddin, A Mazumder, MS Yar… - Synthetic …, 2017 - Taylor & Francis
The new era of heterocyclic moieties which are developed in the decades plays a very
important role in the treatment of various diseases. Among them are 1, 3, 4-oxadiazoles, a …

Synthesis and In Vitro and In Vivo Biological Activity Evaluation and Quantitative Proteome Profiling of Oxadiazoles Bearing Flexible Heterocyclic Patterns

QQ Tao, LW Liu, PY Wang, QS Long… - Journal of agricultural …, 2019 - ACS Publications
A novel series of simple 1, 3, 4-oxadiazoles that bear flexible heterocyclic patterns was
prepared, and their biological activities in plant pathogenic bacteria, fungi, oomycetes, and …

Heterocycle compounds with antimicrobial activity

M Fesatidou, A Petrou, G Athina - Current pharmaceutical …, 2020 - ingentaconnect.com
Background: Bacterial infections are a growing problem worldwide causing morbidity and
mortality mainly in developing countries. Moreover, the increased number of …

Rational optimization and action mechanism of novel imidazole (or imidazolium)-labeled 1, 3, 4-oxadiazole thioethers as promising antibacterial agents against plant …

PY Wang, MW Wang, D Zeng, M Xiang… - Journal of agricultural …, 2019 - ACS Publications
The emergence and widespread occurrence of plant bacterial diseases that cause global
production constraints have become major challenges to agriculture worldwide. To promote …

Design, synthesis, and antimicrobial behavior of novel oxadiazoles containing various N‐containing heterocyclic pendants

D Zeng, MW Wang, M Xiang, LW Liu… - Pest Management …, 2020 - Wiley Online Library
BACKGROUND The gradually elevated outbreak of plant bacterial diseases severely limits
agricultural products and small amounts of pesticides can manage them. Our group has …

1, 3, 4-Oxadiazole containing compounds as therapeutic targets for cancer therapy

MJ Ahsan - Mini Reviews in Medicinal Chemistry, 2022 - ingentaconnect.com
Background: Cancer is the first or second leading cause of premature death in 134 of 183
countries in the world. 1, 3, 4-Oxadiazoles are five membered heterocyclic rings containing …

A review of the biological activities of heterocyclic compounds comprising oxadiazole moieties

BF Ruan, QL Guo, QS Li, LZ Li… - Current Topics in …, 2022 - ingentaconnect.com
The oxadiazole core is considered a privileged moiety in many medicinal chemistry
applications. The oxadiazole class includes 1, 2, 3-oxadiazole, 1, 2, 4-oxadiazole, 1, 3, 4 …