Failed proteostasis is a well-documented feature of Alzheimer's disease, particularly,
reduced protein degradation and clearance. However, the contribution of failed proteostasis …

Alzheimer's disease (AD) is the most prevalent dementia, pathologically featuring abnormal
accumulation of amyloid-β (A β) and hyperphosphorylated tau, while sleep, divided into …

Acute sleep deprivation has been shown to affect cerebrospinal fluid and plasma
concentrations of biomarkers associated with neurodegeneration, though the mechanistic …

Astrocytes interact with various cell types, including neurons, vascular cells, microglia, and
peripheral immune cells. These interactions are crucial for regulating normal brain functions …

Background A few studies have suggested that light at night (LAN) exposure, ie lighting
during night hours, may increase dementia risk. We evaluated such association in a cohort …

Background Identifying risk factors for Alzheimer disease in women is important as women
compose two-thirds of individuals with Alzheimer disease. Previous work links vasomotor …

Alzheimer's disease (AD) is a leading cause of mortality and morbidity among aging
populations worldwide. Despite arduous research efforts, treatment options for this …

Clearance of brain toxins occurs during sleep, although the mechanism remains unknown.
Previous studies implied that the intracranial aqueductal cerebrospinal fluid (CSF) …

Sleep has been postulated to play an important role in the removal of potentially neurotoxic
molecules, such as amyloid-β, from the brain via the glymphatic system. Disturbed sleep, on …

Objective To explore the trajectories of cognitive function development and predictive factors
in disabled middle-aged and older adults. Methods Utilizing data from 983 disabled middle …