Attachment of ubiquitin or ubiquitin-like proteins (known as UBLs) to their targets through
multienzyme cascades is a central mechanism to modulate protein functions. This process is …

Neuronal death underlies the symptoms of many human neurological disorders, including
Alzheimer's, Parkinson's and Huntington's diseases, stroke, and amyotrophic lateral …

The clinical development of an inhibitor of cellular proteasome function suggests that
compounds targeting other components of the ubiquitin–proteasome system might prove …

Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …

In AD, an imbalance between Aβ production and removal drives elevated brain Aβ levels
and eventual amyloid plaque deposition. APP undergoes nonamyloidogenic processing via …

Bromodeoxyuridine (BrdU) is a thymidine analog that incorporates DNA of dividing cells
during the S-phase of the cell cycle. As such, BrdU is used for birth dating and monitoring …

The only reported role for the conjugation of the NEDD8 ubiquitin-like molecule is control of
the activity of SCF ubiquitin ligase complexes. Here, we show that the Mdm2 RING finger E3 …

Aging is the biggest risk factor for the development of Alzheimer's disease (AD). Here, we
performed a whole-genome CRISPR screen to identify regulators of neuronal age and show …

Although MDM2 plays a major role in regulating the stability of the p53 tumor suppressor
protein, other poorly understood MDM2-independent pathways also exist. Human …

There are many lines of evidence showing that oxidative stress and aberrant mitogenic
changes have important roles in the pathogenesis of Alzheimer's disease (AD). However …