For the past 20 years, the Clusters of Orthologous Genes (COG) database had been a
popular tool for microbial genome annotation and comparative genomics. Initially created for …

Gene duplication is an important evolutionary mechanism allowing to provide new genetic
material and thus opportunities to acquire new gene functions for an organism, with major …

OrthoDB provides evolutionary and functional annotations of genes in a diverse sampling of
eukaryotes, prokaryotes, and viruses. Genomics continues to accelerate our exploration of …

Abstract OrthoDB (https://www. orthodb. org) provides evolutionary and functional
annotations of orthologs. This update features a major scaling up of the resource coverage …

Abstract eggNOG is a public resource that provides Orthologous Groups (OGs) of proteins at
different taxonomic levels, each with integrated and summarized functional annotations …

Genome-scale human protein–protein interaction networks are critical to understanding cell
biology and interpreting genomic data, but challenging to produce experimentally. Through …

Abstract Since 1992, FlyBase (flybase. org) has been an essential online resource for the
Drosophila research community. Concentrating on the most extensively studied species …

OrthoDB provides evolutionary and functional annotations of orthologs, inferred for a vast
number of available organisms. OrthoDB is leading in the coverage and genomic diversity …

Summary Butterflies (Papilionoidea), with over 18,000 described species [1], have
captivated naturalists and scientists for centuries. They play a central role in the study of …

OrthoDB is a comprehensive catalog of orthologs, genes inherited by extant species from a
single gene in their last common ancestor. In 2016 OrthoDB reached its 9th release, growing …