The science of stroke: mechanisms in search of treatments
MA Moskowitz, EH Lo, C Iadecola - Neuron, 2010 - cell.com
This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …
Plasticity during stroke recovery: from synapse to behaviour
Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which
results in damage to neuronal networks and the impairment of sensation, movement or …
results in damage to neuronal networks and the impairment of sensation, movement or …
Capillary pericytes regulate cerebral blood flow in health and disease
Increases in brain blood flow, evoked by neuronal activity, power neural computation and
form the basis of BOLD (blood-oxygen-level-dependent) functional imaging. Whether blood …
form the basis of BOLD (blood-oxygen-level-dependent) functional imaging. Whether blood …
Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke
Brain endothelial cells form a paracellular and transcellular barrier to many blood-borne
solutes via tight junctions (TJs) and scarce endocytotic vesicles. The blood-brain barrier …
solutes via tight junctions (TJs) and scarce endocytotic vesicles. The blood-brain barrier …
The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow
What is the nature of the vascular architecture in the cortex that allows the brain to meet the
energy demands of neuronal computations? We used high-throughput histology to …
energy demands of neuronal computations? We used high-throughput histology to …
3D transcranial ultrasound localization microscopy in the rat brain with a multiplexed matrix probe
A Chavignon, B Heiles, V Hingot… - IEEE Transactions …, 2021 - ieeexplore.ieee.org
Objective: Ultrasound Localization Microscopy (ULM) provides images of the
microcirculation in-depth in living tissue. However, its implementation in two-dimension is …
microcirculation in-depth in living tissue. However, its implementation in two-dimension is …
Cerebrovascular smooth muscle cells as the drivers of intramural periarterial drainage of the brain
The human brain is the organ with the highest metabolic activity but it lacks a traditional
lymphatic system responsible for clearing waste products. We have demonstrated that the …
lymphatic system responsible for clearing waste products. We have demonstrated that the …
In Vivo Tumor Targeting and Image-Guided Drug Delivery with Antibody-Conjugated, Radiolabeled Mesoporous Silica Nanoparticles
Since the first use of biocompatible mesoporous silica (mSiO2) nanoparticles as drug
delivery vehicles, in vivo tumor targeted imaging and enhanced anticancer drug delivery has …
delivery vehicles, in vivo tumor targeted imaging and enhanced anticancer drug delivery has …
Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain
The cerebral vascular system services the constant demand for energy during neuronal
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …
activity in the brain. Attempts to delineate the logic of neurovascular coupling have been …
Principles of two-photon excitation microscopy and its applications to neuroscience
The brain is complex and dynamic. The spatial scales of interest to the neurobiologist range
from individual synapses (∼ 1 μm) to neural circuits (centimeters); the timescales range from …
from individual synapses (∼ 1 μm) to neural circuits (centimeters); the timescales range from …