Malaria vaccines since 2000: progress, priorities, products
PE Duffy, J Patrick Gorres - npj Vaccines, 2020 - nature.com
Malaria vaccine development entered a new era in 2015 when the pre-erythrocytic
Plasmodium falciparum candidate RTS, S was favorably reviewed by the European …
Plasmodium falciparum candidate RTS, S was favorably reviewed by the European …
[HTML][HTML] Biomaterials for stem cell engineering and biomanufacturing
Recent years have witnessed the expansion of tissue failures and diseases. The uprising of
regenerative medicine converges the sight onto stem cell-biomaterial based therapy. Tissue …
regenerative medicine converges the sight onto stem cell-biomaterial based therapy. Tissue …
Reduced blood-stage malaria growth and immune correlates in humans following RH5 vaccination
Background Development of an effective vaccine against the pathogenic blood-stage
infection of human malaria has proved challenging, and no candidate vaccine has affected …
infection of human malaria has proved challenging, and no candidate vaccine has affected …
Human antibodies that slow erythrocyte invasion potentiate malaria-neutralizing antibodies
DGW Alanine, D Quinkert, R Kumarasingha… - Cell, 2019 - cell.com
The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is the leading
target for next-generation vaccines against the disease-causing blood-stage of malaria …
target for next-generation vaccines against the disease-causing blood-stage of malaria …
Heterotypic interactions drive antibody synergy against a malaria vaccine candidate
RJ Ragotte, D Pulido, AM Lias, D Quinkert… - Nature …, 2022 - nature.com
Understanding mechanisms of antibody synergy is important for vaccine design and
antibody cocktail development. Examples of synergy between antibodies are well …
antibody cocktail development. Examples of synergy between antibodies are well …
Current challenges in vaccinology
RB Kennedy, IG Ovsyannikova, P Palese… - Frontiers in …, 2020 - frontiersin.org
The development of vaccines, which prime the immune system to respond to future
infections, has led to global declines in morbidity and mortality from dreadful infectious …
infections, has led to global declines in morbidity and mortality from dreadful infectious …
[HTML][HTML] Delayed boosting improves human antigen-specific Ig and B cell responses to the RH5. 1/AS01B malaria vaccine
Modifications to vaccine delivery that increase serum antibody longevity are of great interest
for maximizing efficacy. We have previously shown that a delayed fractional (DFx) dosing …
for maximizing efficacy. We have previously shown that a delayed fractional (DFx) dosing …
Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex
BG Williams, LDW King, D Pulido, D Quinkert… - Nature …, 2024 - nature.com
Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium
falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) …
falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) …
Superior antibody immunogenicity of a viral-vectored RH5 blood-stage malaria vaccine in Tanzanian infants as compared to adults
SE Silk, WF Kalinga, IM Mtaka, NS Lilolime, M Mpina… - Med, 2023 - cell.com
Background RH5 is a leading blood-stage candidate antigen for a Plasmodium falciparum
vaccine; however, its safety and immunogenicity in malaria-endemic populations are …
vaccine; however, its safety and immunogenicity in malaria-endemic populations are …
Analysis of the diverse antigenic landscape of the malaria protein RH5 identifies a potent vaccine-induced human public antibody clonotype
JR Barrett, D Pipini, ND Wright, AJR Cooper, G Gorini… - Cell, 2024 - cell.com
The highly conserved and essential Plasmodium falciparum reticulocyte-binding protein
homolog 5 (PfRH5) has emerged as the leading target for vaccines against the disease …
homolog 5 (PfRH5) has emerged as the leading target for vaccines against the disease …