Over the past decade, there has been an unprecedented international focus on improved
quality and availability of medical care, which has reignited interest in clinical automation …

Blood glucose control algorithms have evolved since the beginnings of the artificial
pancreas in diabetes treatment. Although the main problem to solve remains as the …

Background and objective: Glycemic control, especially meal-related disturbance rejection,
has proven to be a major challenge for people with type 1 diabetes. In this manuscript, we …

This work presents a pulsatile Zone Model Predictive Control (pZMPC) for the control of
blood glucose concentration (BGC) in patients with Type 1 Diabetes Mellitus (T1DM). The …

Background: Despite the recent advancements in the modeling of glycemic dynamics for
type 1 diabetes mellitus, automatically considering unannounced meals and exercise …

An adaptive and personalized multivariable artificial pancreas (mAP) system using plasma
insulin estimates is proposed to efficiently accommodate major disturbances to the blood …

In silico simulations have become essential for the development of diabetes treatments.
However, currently available simulators are not challenging enough and often suffer from …

Background: Either under standard basal-bolus treatment or hybrid closed-loop control,
subjects with type 1 diabetes are required to count carbohydrates (CHOs). However, CHO …

Background: Emerging therapies such as closed-loop (CL) glucose control, also known as
artificial pancreas (AP) systems, have shown significant improvement in type 1 diabetes …

In the present work, an augmented subcutaneous (SC) model of type 1 diabetic patients
(T1DP) is proposed first by estimating the model parameters with the aid of nonlinear least …