Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …

Mood disorders account for a significant global disease burden, and pharmacological
innovation is needed as existing medications are suboptimal. A wide range of evidence …

The circadian clock is an intracellular timekeeping device that drives daily rhythms in diverse
and extensive processes throughout the body. The clock mechanism comprises a core …

Circadian rhythms are natural rhythms that widely exist in all creatures, and regulate the
processes and physiological functions of various biochemical reactions. The circadian clock …

Despite strict measures taken by many countries, severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) continues to be an issue of global concern. Currently, there are …

Circadian rhythms are genetically encoded molecular clocks for internal biological
timekeeping. Organisms from single-cell bacteria to humans use these clocks to adapt to the …

Disruption of circadian oscillations has a wide-ranging impact on health, with the potential to
induce the development of clock-related diseases. Small-molecule modulators of the …

The circadian clock coordinates physiology, metabolism, and behavior with the 24-h cycles
of environmental light. Fundamental mechanisms of how the circadian clock regulates organ …

Circadian rhythm is an important mechanism that controls behavior and biochemical events
based on 24 h rhythmicity. Ample evidence indicates disturbance of this mechanism is …

Cryptochromes are negative transcriptional regulators of the circadian clock in mammals. It
is not clear how reducing the level of endogenous CRY1 in mammals will affect circadian …