In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

Cardiac alternans arises from dynamical instabilities in the electrical and calcium cycling
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …

Ventricular fibrillation (VF) is one of the main causes of death in the Western world.
According to one hypothesis, the chaotic excitation dynamics during VF are the result of …

Spatially confined rigid membranes reorganize their morphology in response to the imposed
constraints. A crumpled elastic sheet presents a complex pattern of random folds focusing …

T-wave alternans, a powerful marker of arrhythmic events, results from alternation in action
potential duration (APD). The underlying cellular mechanism of APD alternans is unknown …

We examine the utility of the action potential (AP) duration (APD) restitution curve slope in
predicting the onset of electrical alternans when electrotonic and memory effects are …

We investigate numerically and analytically the coupled dynamics of transmembrane
voltage and intracellular calcium cycling in paced cardiac cells using a detailed …

The beating of the heart is a synchronized contraction of muscle cells (myocytes) that is
triggered by a periodic sequence of electrical waves (action potentials) originating in the …

Many natural and man-made systems are prone to critical transitions—abrupt and potentially
devastating changes in dynamics. Deep learning classifiers can provide an early warning …

Pre-existing heterogeneities present in cardiac tissue are essential for maintaining the
normal electrical and mechanical functions of the heart. Exacerbation of such …