Quinolone antimicrobials are synthetic and widely used in clinical medicine. Resistance
emerged with clinical use and became common in some bacterial pathogens. Mechanisms …

Quinolone antimicrobials are widely used in clinical medicine and are the only current class
of agents that directly inhibit bacterial DNA synthesis. Quinolones dually target DNA gyrase …

Plasmid‐mediated quinolone resistance (PMQR) was late in being discovered. Nalidixic
acid, the first quinolone to be used clinically, was introduced in 1967 for urinary tract …

While the description of resistance to quinolones is almost as old as these antimicrobial
agents themselves, transferable mechanisms of quinolone resistance (TMQR) remained …

There is increasing concern that environmental antibiotic pollution promotes transfer of
resistance genes to the human microbiota. Here, fluoroquinolone-polluted river sediment …

Background Quinolones are broad-spectrum antibiotics, which are used for the treatment of
different infectious diseases associated with Enterobacteriaceae. During recent decades …

ComPath is an ongoing European programme dedicated to monitor antibiotic susceptibility
of bacterial pathogens from diseased dogs and cats. The objective was to characterize …

qnrD is a plasmid mediated quinolone resistance gene from unknown origin, recently
described in Enterobacteriaceae. It encodes a pentapeptide repeat protein 36–60% different …

Background Enterobacteria of the genus Providencia are mainly known as opportunistic
human pathogens but have been isolated from highly diverse natural environments. The …

Background Comparative genomics can be an initial step in finding the genetic basis for
phenotypic differences among bacterial strains and species. Bacteria belonging to the …