RNA-based diagnostic markers discovery and therapeutic targets development in cancer

H Wang, Q Meng, J Qian, M Li, C Gu, Y Yang - Pharmacology & …, 2022 - Elsevier
The present review aimed to outline different types of RNAs in cancer diagnostics and
treatment, and to provide novel insights into their clinical applications. RNAs, including …

The RNA-binding protein HuR in human cancer: a friend or foe?

X Wu, L Xu - Advanced drug delivery reviews, 2022 - Elsevier
The RNA-binding proteins (RBPs) are critical trans factors that associate with specific cis
elements present in mRNAs whose stability and translation are subject to regulation. The …

Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms

J Wang, F Wang, J Ke, Z Li, C Xu, Q Yang… - Science Translational …, 2022 - science.org
The role of N 6-methyladenosine (m6A) modifications in renal diseases is largely unknown.
Here, we characterized the role of N 6-adenosine-methyltransferase-like 3 (METTL3), whose …

Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1

CF Zhou, J Ma, L Huang, HY Yi, YM Zhang, XG Wu… - Oncogene, 2019 - nature.com
Cancer-secreted exosomal miRNAs are emerging mediators of cancer-stromal cross-talk in
the tumor environment. Our previous miRNAs array of cervical squamous cell carcinoma …

Mechanisms of action of vitamin D in colon cancer

G Ferrer-Mayorga, MJ Larriba, P Crespo… - The Journal of steroid …, 2019 - Elsevier
Colorectal cancer (CRC) is the neoplasia that is most frequently associated with vitamin D
deficiency in epidemiological and observational studies in terms of incidence and mortality …

Circulating microRNAs as potential biomarkers in pancreatic cancer—advances and challenges

AA Seyhan - International journal of molecular sciences, 2023 - mdpi.com
There is an urgent unmet need for robust and reliable biomarkers for early diagnosis,
prognosis, and prediction of response to specific treatments of many aggressive and deadly …

Trials and tribulations of MicroRNA therapeutics

AA Seyhan - International Journal of Molecular Sciences, 2024 - mdpi.com
The discovery of the link between microRNAs (miRNAs) and a myriad of human diseases,
particularly various cancer types, has generated significant interest in exploring their …

[HTML][HTML] Circulating exosomal circFoxp1 confers cisplatin resistance in epithelial ovarian cancer cells

Y Luo, R Gui - Journal of gynecologic oncology, 2020 - ncbi.nlm.nih.gov
Objective Early detection and treatment are particularly important to epithelial ovarian
cancer (EOC). Studies have shown that circular RNA (circRNA) dysregulation is associated …

Cancer-associated fibroblasts-derived extracellular vesicles carrying lncRNA SNHG3 facilitate colorectal cancer cell proliferation via the miR-34b-5p/HuR/HOXC6 axis

J Zhao, H Lin, K Huang, S Li - Cell Death Discovery, 2022 - nature.com
Abstract Cancer-associated fibroblasts (CAFs)-derived extracellular vesicles (EVs) can
mediate tumorigenesis. Long noncoding RNA (LncRNA) SNHG3 is implicated in colorectal …

miR-22 gene therapy treats HCC by promoting anti-tumor immunity and enhancing metabolism

Y Hu, T Setayesh, F Vaziri, X Wu, ST Hwang, X Chen… - Molecular Therapy, 2023 - cell.com
MicroRNA-22 (miR-22) can be induced by beneficial metabolites that have metabolic and
immune effects, including retinoic acids, bile acids, vitamin D 3, and short-chain fatty acids …