The expanding role of pyridine and dihydropyridine scaffolds in drug design

Y Ling, ZY Hao, D Liang, CL Zhang… - Drug design …, 2021 - Taylor & Francis
Pyridine-based ring systems are one of the most extensively used heterocycles in the field of
drug design, primarily due to their profound effect on pharmacological activity, which has led …

[HTML][HTML] Vitamin B6 and its role in cell metabolism and physiology

M Parra, S Stahl, H Hellmann - Cells, 2018 - mdpi.com
Vitamin B 6 is one of the most central molecules in cells of living organisms. It is a critical co-
factor for a diverse range of biochemical reactions that regulate basic cellular metabolism …

Vitamin B6: a long known compound of surprising complexity

S Mooney, JE Leuendorf, C Hendrickson, H Hellmann - Molecules, 2009 - mdpi.com
In recent years vitamin B6 has become a focus of research describing the compound's
critical function in cellular metabolism and stress response. For many years the sole function …

Vitamin B biosynthesis in plants

S Roje - Phytochemistry, 2007 - Elsevier
The vitamin B complex comprises water-soluble enzyme cofactors and their derivatives that
are essential contributors to diverse metabolic processes in plants as well as in animals and …

Vitamin B6 deficient plants display increased sensitivity to high light and photo-oxidative stress

M Havaux, B Ksas, A Szewczyk, D Rumeau, F Franck… - BMC plant biology, 2009 - Springer
Background Vitamin B6 is a collective term for a group of six interconvertible compounds:
pyridoxine, pyridoxal, pyridoxamine and their phosphorylated derivatives. Vitamin B6 plays …

Rice plastidial NAD‐dependent malate dehydrogenase 1 negatively regulates salt stress response by reducing the vitamin B6 content

N Nan, J Wang, Y Shi, Y Qian, L Jiang… - Plant Biotechnology …, 2020 - Wiley Online Library
Salinity is an important environmental factor that adversely impacts crop growth and
productivity. Malate dehydrogenases (MDH s) catalyse the reversible interconversion of …

[HTML][HTML] The scope of flavin-dependent reactions and processes in the model plant Arabidopsis thaliana

R Eggers, A Jammer, S Jha, B Kerschbaumer… - Phytochemistry, 2021 - Elsevier
Flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) are utilized as
coenzymes in many biochemical reduction-oxidation reactions owing to the ability of the …

Toward eradication of B-vitamin deficiencies: considerations for crop biofortification

S Strobbe, D Van Der Straeten - Frontiers in Plant Science, 2018 - frontiersin.org
'Hidden hunger'involves insufficient intake of micronutrients and is estimated to affect over
two billion people on a global scale. Malnutrition of vitamins and minerals is known to cause …

Enhanced levels of vitamin B6 increase aerial organ size and positively affect stress tolerance in Arabidopsis

M Raschke, S Boycheva, M Crèvecoeur… - The Plant …, 2011 - Wiley Online Library
Vitamin B6 is an essential nutrient in the human diet derived primarily from plant sources.
While it is well established as a cofactor for numerous metabolic enzymes, more recently …

Balancing of B6 Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis

M Colinas, M Eisenhut, T Tohge, M Pesquera… - The Plant …, 2016 - academic.oup.com
Vitamin B6 comprises a family of compounds that is essential for all organisms, most notable
among which is the cofactor pyridoxal 5′-phosphate (PLP). Other forms of vitamin B6 …