The predominant motor features of Parkinson's disease (PD) are caused by degeneration of
dopaminergic neurones and can be reversed in part or whole by dopamine replacement or …

Considerable advances made in defining the aetiology, pathogenesis, and pathology of
Parkinson's disease (PD) have resulted in the development and rapid expansion of the …

The ability to record transient cellular events in the DNA or RNA of cells would enable
precise, large-scale analysis, selection, and reprogramming of heterogeneous cell …

Alterations to myelin may be a core pathological feature of neurodegenerative diseases.
Although white matter microstructural differences have been described in Parkinson's …

In Parkinson's disease (PD), l‐DOPA therapy leads to the emergence of motor complications
including l‐DOPA‐induced dyskinesia (LID). LID relies on a sequence of pre‐and …

Midkine (MK) and pleiotrophin (PTN) are two neurotrophic factors that are highly up‐
regulated in different brain regions after the administration of various drugs of abuse and in …

The motor deficits in Parkinson's disease (PD) have been primarily associated with internally
guided (IG), but not externally guided (EG), tasks. This study investigated the functional …

Pleiotrophin (PTN) is a secreted growth factor, and also a cytokine, associated with the
extracellular matrix, which has recently starting to attract attention as a significant …

Neuroinflammation is a main component of Parkinson's disease (PD) neuropathology,
where unremitting reactive microglia and microglia-secreted soluble molecules such as …

Central nervous system (CNS) inflammation is a key factor in multiple sclerosis (MS).
Invasion of peripheral immune cells into the CNS resulting from an unknown signal or …