Progress in spray-drying of protein pharmaceuticals: Literature analysis of trends in formulation and process attributes

JT Pinto, E Faulhammer, J Dieplinger, M Dekner… - Drying …, 2021 - Taylor & Francis
Spray-drying is an inherently continuous and well-established industrial drying process. It
can accelerate manufacturing of biopharmaceuticals and vaccine products, resulting in both …

[HTML][HTML] Innovative drying technologies for biopharmaceuticals

A Sharma, D Khamar, S Cullen, A Hayden… - International Journal of …, 2021 - Elsevier
In the past two decades, biopharmaceuticals have been a breakthrough in improving the
quality of lives of patients with various cancers, autoimmune, genetic disorders etc. With the …

[HTML][HTML] Stabilizing vaccines via drying: Quality by design considerations

Z Ghaemmaghamian, R Zarghami, G Walker… - Advanced Drug Delivery …, 2022 - Elsevier
Pandemics and epidemics are continually challenging human beings' health and imposing
major stresses on the societies particularly over the last few decades, when their frequency …

Particle engineering principles and technologies for pharmaceutical biologics

D Cun, C Zhang, H Bera, M Yang - Advanced Drug Delivery Reviews, 2021 - Elsevier
The global market of pharmaceutical biologics has expanded significantly during the last few
decades. Currently, pharmaceutical biologic products constitute an indispensable part of the …

[HTML][HTML] Solidification and oral delivery of biologics to the colon-a review

KT Kopp, L Saerens, J Voorspoels… - European Journal of …, 2023 - Elsevier
The oral delivery of biologics such as therapeutic proteins, peptides and oligonucleotides for
the treatment of colon related diseases has been the focus of increasing attention over the …

Advancements in spray drying, part I: From critical factors to variegated applications

Z Li, C Sun, A Naeem, Q Li, L Yang, Z Jin… - Drying …, 2024 - Taylor & Francis
Spray drying (SD) is a unit operation that efficiently converts solutions or suspensions into
solid products in a simple, versatile, and continuous manner. It is widely used across various …

Impact of different saccharides on the in-process stability of a protein drug during evaporative drying: from sessile droplet drying to lab-scale spray drying

J Dieplinger, JT Pinto, M Dekner, G Brachtl… - Pharmaceutical …, 2023 - Springer
Objectives Solid biopharmaceutical products can circumvent lower temperature storage and
transport and increase remote access with lower carbon emissions and energy …

Recent Advances in Drying and Development of Solid Formulations for Stable mRNA and siRNA Lipid Nanoparticles

KS Arte, M Chen, CD Patil, Y Huang, L Qu… - Journal of Pharmaceutical …, 2024 - Elsevier
Current RNA lipid nanoparticle (LNP) based products are typically liquid formulations that
require ultra-cold storage temperatures for stability. To address this limitation, recent efforts …

Influence of L-leucine content on the aerosolization stability of spray-dried protein dry powder inhalation (DPI)

J Dieplinger, AIA Urich, N Mohsenzada, JT Pinto… - International Journal of …, 2024 - Elsevier
Inhalable formulations of medicines intended to act locally in the lung are therapeutically
effective at lower doses with targeted delivery, compared to parenteral or oral administration …

[HTML][HTML] Application of ultraviolet, visible, and infrared light imaging in protein-based biopharmaceutical formulation characterization and development studies

ME Klijn, J Hubbuch - European Journal of Pharmaceutics and …, 2021 - Elsevier
Imaging is increasingly more utilized as analytical technology in biopharmaceutical
formulation research, with applications ranging from subvisible particle characterization to …