Targeting intrinsically disordered transcription factors: changing the paradigm

K Tsafou, PB Tiwari, JD Forman-Kay, SJ Metallo… - Journal of molecular …, 2018 - Elsevier
Increased understanding of intrinsically disordered proteins (IDPs) and protein regions has
revolutionized our view of the relationship between protein structure and function. Data now …

Induced pluripotent stem cells display a distinct set of MHC I-associated peptides shared by human cancers

A Apavaloaei, L Hesnard, MP Hardy, B Benabdallah… - Cell Reports, 2022 - cell.com
Previous reports showed that mouse vaccination with pluripotent stem cells (PSCs) induces
durable anti-tumor immune responses via T cell recognition of some elusive oncofetal …

Alternative pre-mRNA splicing in stem cell function and therapeutic potential: A critical review of current evidence

L Cui, Y Zheng, R Xu, Y Lin, J Zheng, P Lin… - International Journal of …, 2024 - Elsevier
Alternative splicing is a crucial regulator in stem cell biology, intricately influencing the
functions of various biological macromolecules, particularly pre-mRNAs and the resultant …

Therapeutic potential of patient iPSC-derived iMelanocytes in autologous transplantation

LP Liu, YM Li, NN Guo, S Li, X Ma, YX Zhang, Y Gao… - Cell reports, 2019 - cell.com
Induced pluripotent stem cells (iPSCs) are a promising melanocyte source as they
propagate indefinitely and can be established from patients. However, the in vivo functions …

De novo putative loss‐of‐function variants in TAF4 are associated with a neuro‐developmental disorder

BDE Janssen, MJH van den Boogaard… - Human …, 2022 - Wiley Online Library
TATA‐binding protein associated factor 4 (TAF4) is a subunit of the Transcription Factor IID
(TFIID) complex, a central player in transcription initiation. Other members of this multimeric …

BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis

A Delannoy, E Wilhelm, S Eilebrecht… - Cell Death & …, 2018 - nature.com
TAF6δ is a pro-apoptotic splice variant of the RNA polymerase II general transcription factor,
TAF6, that can dictate life vs. death decisions in animal cells. TAF6δ stands out from …

Overexpression of TWA1 predicts poor prognosis in patients with gastric cancer

J Xiong, Z Feng, Z Li, T Zhong, Z Yang, Y Tu… - … -Research and Practice, 2019 - Elsevier
TWA1 is associated with microtubule dynamics, cell migration, nucleokinesis and
chromosome segregation. However, the role of TWA1 in gastric cancer (GC) remains …

Novel tumor-specific antigens for cancer stem cells and uses thereof

C Perreault, P Thibault, MP HARDY, A APAVALOAEI - 2023 - Google Patents
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-
amino-3-phenylpropanoyl] amino]-3-phenylpropanoyl] amino]-4-methylpentanoyl] amino] …

[PDF][PDF] Integrated analysis of genomic, epigenomic and gene expression profiles in multiple datasets

C Viberti - 2018 - iris.unito.it
During my PhD work I was involved in several research projects integrating different omics
data with the aim to identify susceptibility/early detection biomarkers and prognostic factors …