The pleckstrin homology [PH] domain is a structural fold found in more than 250 proteins
making it the 11th most common domain in the human proteome. 25% of family members …

Alzheimer's disease (AD) is a common age-related neurodegenerative disease that leads to
memory loss and cognitive function damage due to intracerebral neurofibrillary tangles …

Background BIOGF1K, a compound K-rich fraction prepared from the root of Panax ginseng,
is widely used for cosmetic purposes in Korea. We investigated the functional mechanisms …

Ethnopharmacological relevance The dried rhizome of Atractylodes lancea (Thumb.)
DC.(Compositae) has been prescribed in folk medicine for the management of various …

Ethnopharmacological relevance The rhizome of Atractylodes chinensis (DC.) kodiz
(Compositae) has traditionally been used to treat inflammatory disorders such as arthritis …

The protein kinase PDK1 phosphorylates at least 24 distinct substrates, all of which belong
to the AGC protein kinase group. Some substrates, such as conventional PKCs, undergo …

Ethnopharmacological relevance Xanthium strumarium L.(Asteraceae) has traditionally
been used to treat bacterial infections, nasal sinusitis, urticaria, arthritis, chronic bronchitis …

Cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) signalling is
essential for the proliferation of Plasmodium falciparum malaria blood stage parasites. The …

Computer-aided drug design (CADD) techniques allow the identification of compounds
capable of modulating protein functions in pathogenesis-related pathways, which is a …

Ethnopharmacological relevance Gastritis can lead to ulcers and the development of gastric
cancer. The rhizome of Atractylodes macrocephala Koidz.(Asteraceae), a traditional …