Processing stimulus dynamics by the NF-κB network in single cells

M Son, AG Wang, B Keisham, S Tay - Experimental & Molecular …, 2023 - nature.com
Cells at the site of an infection experience numerous biochemical signals that vary in
amplitude, space, and time. Despite the diversity of dynamic signals produced by pathogens …

Alternative pre-mRNA splicing as a mechanism for terminating Toll-like Receptor signaling

FFY Lee, S Alper - Frontiers in Immunology, 2022 - frontiersin.org
While inflammation induced by Toll-like receptor (TLR) signaling is required to combat
infection, persistent inflammation can damage host tissues and contribute to a myriad of …

S-allylmercaptocysteine inhibits TLR4-mediated inflammation through enhanced formation of inhibitory MyD88 splice variant in mammary epithelial cells

M Takashima, M Kurita, H Terai, FQ Zhao, J Suzuki - Scientific Reports, 2024 - nature.com
Mastitis is an inflammatory disease affecting mammary tissues caused by bacterial infection
that negatively affects milk quality and quantity. S-Allylmercaptocysteine (SAMC), a sulfur …

Tempol mitigates inflammation, oxidative stress, and histopathological alterations of cadmium-induced parotid gland injury in rats

SS Abd El-Fatah, OE Nafea, DM Yousef, W Samy… - Life Sciences, 2024 - Elsevier
Cadmium (Cd) is a potent environmental pollutant that causes functional and structural
damage to the salivary glands. Tempol (TEM) has powerful antioxidant activity that can …

RNA Binding Proteins that Mediate LPS-induced Alternative Splicing of the MyD88 Innate Immune Regulator

FFY Lee, C Harris, S Alper - Journal of Molecular Biology, 2024 - Elsevier
Inflammation driven by Toll-like receptor (TLR) signaling pathways is required to combat
infection. However, inflammation can damage host tissues; thus it is essential that TLR …

Compound c17 alleviates inflammatory cardiomyopathy in streptozotocin-induced diabetic mice by targeting MyD88

Q Zhang, W Zhu, S Lou, H Bao, Y Zhou, Z Cai… - International …, 2023 - Elsevier
Background Diabetic cardiomyopathy (DCM) is a common complication of diabetes mellitus
and is associated with increased morbidity and mortality due to cardiac dysfunction. Chronic …

下调丝氨酸/精氨酸富集剪接因子6 通过调控髓系分化因子88 选择性剪接抑制巨噬细胞炎症反应.

付育, 张璐瑶, 程博, 石炜业, 李霓… - Chinese Journal of …, 2024 - search.ebscohost.com
摘要丝氨酸/精氨酸富集剪接因子6 (serine/arginine⁃ rich splicing factor 6, SRSF6) 属于SR
蛋白家族, 主要在RNA 剪接中发挥调控作用. SRSF6 表达或功能失调能够导致部分基因选择性 …

From Monomers to Oligomers: Structural Mechanism of Receptor-Triggered MyD88 Assembly in Innate Immune Signaling

K Kasai, K Imamura, M Uno, N Sekiyama, T Miyata… - bioRxiv, 2024 - biorxiv.org
MyD88 plays a pivotal role in Toll-like receptor (TLR) and interleukin-1 family signaling
through its oligomerization upon receptor activation, leading to downstream protein …

Protein supersaturation powers innate immune signaling

AR Gama, T Miller, J Lange, J Wu, JR Unruh… - Biophysical …, 2024 - cell.com
The response of cells to existential threats such as virus invasion often involves semi-
crystalline polymerization of certain signaling proteins, but the highly ordered nature of the …

Valoración de dos biomarcadores inmunológicos en sepsis bacteriana y shock séptico

EP Merlano, AP Barrera, RN Quiroz… - Acta Colombiana de …, 2024 - Elsevier
Introducción La sepsis es un trastorno que puede progresar al shock, con falla
multiorgánica e incrementándose la mortalidad, por lo que el estudio de biomarcadores de …