Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Co-amorphous drug delivery systems have recently gained considerable interest in the
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …

Phase transition issues in the field of foods and drugs have significantly influenced these
industries and consequently attracted the attention of scientists and engineers. The study of …

Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV
APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with …

Although it has long been recognized that dynamics in supercooled liquids might be
spatially heterogeneous, only in the past few years has clear evidence emerged to support …

It is now just about 10 years since the publication of the first edition of Polymorphism in
Pharmaceutical Solids, which certainly received a positive reaction from workers in drug …

Purpose. To evaluate the magnitude of the solubility advantage foramorphous
pharmaceutical materials when compared to their crystallinecounterparts. Methods. The …

Amorphous solid dispersions are an increasingly important formulation approach to improve
the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their …

It has been nearly a decade since the third edition of Engineering Properties of Foods was
published, and food structure/microstructure remains a subject of research interest. In fact …

Purpose To investigate the underlying physical processes taking place during dissolution of
amorphous pharmaceuticals and correlate them to the observed solution concentration-time …