Humanized yeast to model human biology, disease and evolution

AH Kachroo, M Vandeloo, BM Greco… - Disease models & …, 2022 - journals.biologists.com
For decades, budding yeast, a single-cellular eukaryote, has provided remarkable insights
into human biology. Yeast and humans share several thousand genes despite …

Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture

HJ Cha, Ö Uyan, Y Kai, T Liu, Q Zhu, Z Tothova… - Nature …, 2021 - nature.com
Precise control of gene expression during differentiation relies on the interplay of chromatin
and nuclear structure. Despite an established contribution of nuclear membrane proteins to …

Systematic profiling of ale yeast protein dynamics across fermentation and repitching

RK Garge, RC Geck, JO Armstrong… - G3: Genes …, 2024 - academic.oup.com
Studying the genetic and molecular characteristics of brewing yeast strains is crucial for
understanding their domestication history and adaptations accumulated over time in …

[HTML][HTML] A Humanized Yeast Model for Studying TRAPP Complex Mutations; Proof-of-Concept Using Variants from an Individual with a TRAPPC1-Associated …

E Zykaj, C Abboud, P Asadi, S Warsame, H Almousa… - Cells, 2024 - mdpi.com
Variants in membrane trafficking proteins are known to cause rare disorders with severe
symptoms. The highly conserved transport protein particle (TRAPP) complexes are key …

Structural Changes, Biological Consequences, and Repurposing of Colchicine Site Ligands

F Montecinos, DL Sackett - Biomolecules, 2023 - mdpi.com
Microtubule-targeting agents (MTAs) bind to one of several distinct sites in the tubulin dimer,
the subunit of microtubules. The binding affinities of MTAs may vary by several orders of …

Spiromesifen contributes vascular developmental toxicity via disrupting endothelial cell proliferation and migration in zebrafish embryos

M Wang, J Liu, H Wang, T Hu - Pesticide Biochemistry and Physiology, 2022 - Elsevier
Spiromesifen (SPF) is a specific contact pesticide, which has been widely used to control the
growth of sucking insects like mites and whiteflies on crops. Although its residues in crops …